A New Generation of Selective Androgen Receptor Degraders : Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

Hwang , D-J , He , Y , Ponnusamy , S , Mohler , M L , Thiyagarajan , T , McEwan , I J , Narayanan , R & Miller , D D 2019 , ' A New Generation of Selective Androgen Receptor Degraders : Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity ' , Journal of Medicinal Chemistry , vol. 62 , no. 2 , pp. 491-511 . https://doi.org/10.1021/acs.jmedchem.8b00973

Publication

Journal of Medicinal Chemistry

Status

Peer reviewed

DOI

https://doi.org/https://doi.org/10.1021/acs.jmedchem.8b00973

ISSN

0022-2623

Type

Journal article

Description

This research was supported by the Van Vleet Endowed Professorship (D.D.M.), and GTx, Inc. grant (R.N. and D.D.M.) We thank GTx, Inc. for supporting this project and Dr. Dejian Ma of UTHSC, College of Pharmacy for assistance with 2D NMR and HRMS experiments.

AURA - Aberdeen University Research Archive