Bone Regeneration Using Porous Titanium Particles versus Bovine Hydroxyapatite: A Sinus Lift Study in Rabbits.

[en] Aim: The first objective of this study was to qualitatively and quantitatively assess the bone formation process, particularly the long-term behavior and three-dimensional volume stability of subsinusal bone regeneration, using titanium (Ti) or bovine hydroxyapatite (BHA) granules, in a rabbit model. The second objective was to evaluate the effect of the hydration of the BHA particles with a therapeutic concentration of doxycycline solution on the osteogenesis and biomaterial resorption. Materials and Methods: Rabbits underwent a double sinus lift procedure using one of three materials: grade 1 porous Ti particles, BHA, or BHA hydrated with doxycycline solution (0.1 mg/ml) (BHATTC). Animals were sacrificed after 1 week, 5 weeks, or 6 months. Samples were analyzed using µCT and nondecalcified histology. Results: The materials used in each of the three groups allowed an optimal bone formation; bone quantities and densities were not statistically different between the three groups. At 6 months, more stable three-dimensional volume stability was found with Ti and BHATTC (p = .0033). At 5 weeks and 6 months, bone to material contact corroborating osteoconduction was significantly higher with BHA and BHATTC than with Ti (p < .0001). Conclusions and Clinical Implications: Even though the studied biomaterials displayed different architectures, they are relevant candidates for sinus lift bone augmentation prior to dental implants because they allow adequate three-dimensional stability and osteogenesis. However, to recommend the clinical use of Ti, both an observation on the drilling effects of Ti particles and clinical trials are needed.

Disciplines :

Dentistry & oral medicine

Author, co-author :

LAMBERT, France ; Centre Hospitalier Universitaire de Liège - CHU > Médecine dentaire

LECLOUX, Geoffrey ; Centre Hospitalier Universitaire de Liège - CHU > Médecine dentaire

Léonard, Angélique ; Université de Liège - ULiège > Département de chimie appliquée > Génie chimique - Procédés et développement durable

Sourice, S.

Layrolle, P.

ROMPEN, Eric ; Centre Hospitalier Universitaire de Liège - CHU > Médecine dentaire

Language :

English

Title :

Bone Regeneration Using Porous Titanium Particles versus Bovine Hydroxyapatite: A Sinus Lift Study in Rabbits.

Publication date :

2013

Journal title :

Clinical Implant Dentistry and Related Research

ISSN :

1523-0899

eISSN :

1708-8208

Publisher :

Blackwell Publishing

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 15 November 2011

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