Article (Scientific journals)
Hierarchical clustering of brain activity during human nonrapid eye movement sleep.
Boly, Mélanie; Perlbarg, V; Marrelec, G et al.
2012In Proceedings of the National Academy of Sciences of the United States of America
Peer Reviewed verified by ORBi
 

Files


Full Text
Boly_PNAS_2012.pdf
Publisher postprint (278.49 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Consciousness is reduced during nonrapid eye movement (NREM) sleep due to changes in brain function that are still poorly understood. Here, we tested the hypothesis that impaired consciousness during NREM sleep is associated with an increased modularity of brain activity. Cerebral connectivity was quantified in resting-state functional magnetic resonance imaging times series acquired in 13 healthy volunteers during wakefulness and NREM sleep. The analysis revealed a modification of the hierarchical organization of large-scale networks into smaller independent modules during NREM sleep, independently from EEG markers of the slow oscillation. Such modifications in brain connectivity, possibly driven by sleep ultraslow oscillations, could hinder the brain's ability to integrate information and account for decreased consciousness during NREM sleep.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Boly, Mélanie ;  Université de Liège - ULiège > Centre de recherches du cyclotron - Coma Science Group - Département des sciences cliniques > Neurologie
Perlbarg, V
Marrelec, G
Schabus, M
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron - Coma Science Group
Doyon, J
Pelegrini-Issac, M
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Benali, H
Language :
English
Title :
Hierarchical clustering of brain activity during human nonrapid eye movement sleep.
Publication date :
2012
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FMRE - Fondation Médicale Reine Elisabeth [BE]
Funding text :
European Sleep Research Grant
Available on ORBi :
since 29 April 2012

Statistics


Number of views
119 (6 by ULiège)
Number of downloads
237 (10 by ULiège)

Scopus citations®
 
135
Scopus citations®
without self-citations
111
OpenCitations
 
148

Bibliography


Similar publications



Contact ORBi