Article (Scientific journals)
New role for Emerin, a key inner nuclear membrane protein, as an enhancer of the autophagosome formation in the C16-ceramide autophagy pathway.
Deroyer, Céline; Renert, Anne-Françoise; Merville, Marie-Paule et al.
2014In Autophagy
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Keywords :
ceramide; autophagy; emerine
Abstract :
[en] To date, precise roles of EMD remain poorly described. In this paper, we investigate the role of EMD in the C16-ceramide autophagy pathway. Ceramides are bioactive signalling molecules acting notably in the regulation of cell growth, differentiation or cell death. However, the mechanisms by which they mediate these pathways are not fully understood. We found that C16-ceramide induces EMD phosphorylation on its LEM domain through PRKACA. Upon ceramide treatment, phosphorylated EMD binds LC3 leading to an increase of the autophagosomes formation. These data suggest a new role of EMD as an enhancer of autophagosomes formation in the C16-ceramide autophagy pathway in colon cancer cells.
Research center :
Giga-Signal Transduction - ULiège
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Deroyer, Céline  ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Renert, Anne-Françoise
Merville, Marie-Paule ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Fillet, Marianne ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Language :
English
Title :
New role for Emerin, a key inner nuclear membrane protein, as an enhancer of the autophagosome formation in the C16-ceramide autophagy pathway.
Publication date :
2014
Journal title :
Autophagy
ISSN :
1554-8627
eISSN :
1554-8635
Publisher :
Landes Bioscience, Georgetown, United States - Texas
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
ULg - Université de Liège [BE]
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