Article (Scientific journals)
Effect Of Bovine Colostrum Supplementation On Cytokine mRNA Expression In Weaned Piglets
Boudry, Christelle; Buldgen, André; Portetelle, Daniel et al.
2007In Livestock Science, 108 (1-3), p. 295-298
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Keywords :
piglet; bovine colostrum; cytokine; Th1/Th2; RT-PCR
Abstract :
[en] The aim of this study was to evaluate the influence of a bovine colostrum supplementation on the immune Th1/Th2 response in weaned piglets. After weaning at 21 days, 21 piglets were fed daily ad libitum with a starter diet supplemented for 3 weeks with 0, 1 or 5 g of bovine colostrum. Growth performances were measured weekly. Spleen and gut-associated lymphoid tissues (GALT) (ileal Peyer’s patch (iPP), jejunum wall (JW) and mesenteric lymph nodes (MLN)) biopsies were collected on each piglet after the 3 weeks treatment and analyzed for their cytokine mRNA expression (IL-2, IL-4, IL-10, IL-12 and IFN) by RT-PCR. Growth performances were not affected by bovine colostrum (P > 0.05). In the colostrum groups, the iPP cells showed higher IL-4, IL-10 and IL-12 cytokine levels (P < 0,05), associated with a decrease of IFN-γ (P < 0,01) and no effect on IL-2 production (P > 0,05). IL-10, IL-2 and IL-12 productions increased (P < 0,05) in MLN, with no effect on IFN-γ and IL-4 levels (P > 0,05). The IL-12 production was also increased (P < 0,01) in JW cells with no modification for the other cytokine. No modification of cytokine production was observed in the spleen (P > 0,05). These results suggest an immunomodulatory effect of bovine colostrum on the GALT which answered by producing, at different levels, both Th1 pro-inflammatory cytokines - IL-2, IFN-γ and IL-12 - and Th2 anti-inflammatory cytokines - IL-4 and IL-10. This bipolarity of the Th1/Th2 response protects the weaned piglets from both allergic (food) as well as infectious (pathogens) diseases.
Disciplines :
Veterinary medicine & animal health
Agriculture & agronomy
Author, co-author :
Boudry, Christelle ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Buldgen, André;  Université de Liège > Gembloux Agro-Bio Tech
Portetelle, Daniel ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Gianello, Pierre;  Université Catholique de Louvain - UCL > Faculté de Médecine > Unité de Chirugie expérimentale
Thewis, André ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Leterme, Pascal;  Prairie Swine Centre, Saskatoon, Canada
Dehoux, Jean-paul;  Université Catholique de Louvain - UCL > Faculté de Médecine > Unité de Chirurgie Expérimentale
Language :
English
Title :
Effect Of Bovine Colostrum Supplementation On Cytokine mRNA Expression In Weaned Piglets
Alternative titles :
[fr] Effet d'une supplémentation en colostrum bovin sur l'expression de l'ARNm des cytokines chez le porcelet au sevrage
Publication date :
2007
Journal title :
Livestock Science
ISSN :
1871-1413
eISSN :
1878-0490
Publisher :
Elsevier B.V.
Volume :
108
Issue :
1-3
Pages :
295-298
295-298
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
DGTRE - Région wallonne. Direction générale des Technologies, de la Recherche et de l'Énergie [BE]
DGA - Région wallonne. Direction générale de l'Agriculture [BE]
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