[en] In several animal species including humans, the acute administration of low doses of alcohol increasesmotor activity. Different theories have postulated that alcohol-induced hyperactivity is causally related to alcoholism.Moreover, a common biological mechanism in the mesolimbic dopamine system has been proposed to mediate the stimulant and motivational effects of alcohol. Numerous studies have examined whether alcohol-induced hyperactivity is related to alcoholism using a great variety of animal models and several animal species. However, there is no review that has summarized this extensive literature. In this article, we present the various experimental models that have been used to study the relationship between the stimulant and motivational effects of alcohol in rodents and primates. Furthermore, we discuss whether the theories hypothesizing a causal link between alcohol-induced hyperactivity and alcoholism are supported by published results. The reviewed findings indicate that animal species that are stimulated by alcohol also exhibit alcohol preference. Additionally, the role of dopamine in alcohol-induced hyperactivity is well established since blocking dopaminergic activity suppresses the stimulant effects of alcohol. However, dopamine transmission plays a much more complex function in the motivational properties of alcohol and the neuronal mechanisms involved in alcohol stimulation and reward are distinct. Overall, the current review provides mixed support for theories suggesting that the stimulant effects of alcohol are related to alcoholism and highlights the importance of animal models as a way to gain insight into alcoholism.
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M.A. Addicott, D.M. Marsh-Richard, C.W. Mathias, and D.M. Dougherty The biphasic effects of alcohol: comparisons of subjective and objective measures of stimulation, sedation, and physical activity Alcohol Clin Exp Res 31 2007 1883 1890
R. Agabio, M.A. Carai, C. Lobina, M. Pani, R. Reali, and G. Vacca et al. Alcohol stimulates motor activity in selectively bred Sardinian alcohol-preferring (sP), but not in Sardinian alcohol-nonpreferring (sNP), rats Alcohol 23 2001 123 126
S. Ahlenius, A. Carlsson, J. Engel, T. Svensson, and P. Södersten Antagonism by alpha methyltyrosine of the ethanol-induced stimulation and euphoria in man Clin Pharmacol Ther 14 1973 586 591
American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders: DSM-IV - 4th Revision 2000 American Psychiatric Press Washington, DC
C. Arias, E.C. Mlewski, J.C. Molina, and N.E. Spear Ethanol induces locomotor activating effects in preweanling Sprague-Dawley rats Alcohol 43 2009 13 23
C. Arias, E.C. Mlewski, C. Hansen, J.C. Molina, M.G. Paglini, and N.E. Spear Dopamine receptors modulate ethanol's locomotor-activating effects in preweanling rats Dev Psychobiol 52 2010 13 23
M.N. Arizzi-LaFrance, M. Correa, C.M. Aragon, and J.D. Salamone Motor stimulant effects of ethanol injected into the substantia nigra pars reticulata: importance of catalase-mediated metabolism and the role of acetaldehyde Neuropsychopharmacology 31 2006 997 1008
A. Arvola, and O. Forsander Comparison between water and alcohol consumption in six animal species in free-choice experiments Nature 191 1961 819 820
K.E. Asin, D. Wirtshafter, and B. Tabakoff Failure to establish a conditioned place preference with ethanol in rats Pharmacol Biochem Behav 22 1985 169 173
M.T. Bardo, and R.A. Bevins Conditioned place preference: what does it add to our preclinical understanding of drug reward? Psychopharmacology (Berl) 153 2000 31 43
C.S. Barr, M. Schwandt, S.G. Lindell, S.A. Chen, D. Goldman, and S.J. Suomi et al. Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques Arch Gen Psychiatry 64 2007 369 376
S.P. Barrett, R.O. Pihl, C. Benkelfat, C. Brunelle, S.N. Young, and M. Leyton The role of dopamine in alcohol self-administration in humans: individual differences Eur Neuropsychopharmacol 18 2008 439 447
H.C. Becker, and M.F. Lopez Increased ethanol drinking after repeated chronic ethanol exposure and withdrawal experience in C57BL/6 mice Alcohol Clin Exp Res 28 2004 1829 1838
M.J. Beckstead, and T.J. Phillips Mice selectively bred for high- or low-alcohol-induced locomotion exhibit differences in dopamine neuron function J Pharmacol Exp Ther 329 2009 342 349
J.K. Belknap, J.C. Crabbe, and E.R. Young Voluntary consumption of ethanol in 15 inbred mouse strains Psychopharmacology (Berl) 112 1993 503 510
R.L. Bell, Z.A. Rodd, L. Lumeng, J.M. Murphy, and W.J. McBride The alcohol-preferring P rat and animal models of excessive alcohol drinking Addict Biol 11 2006 270 288
Y. Ben-Ari Excitatory actions of GABA during development: the nature of the nurture Nat Rev Neurosci 3 2002 728 739
M.E. Benwell, and D.J. Balfour The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity Br J Pharmacol 105 1992 849 856
D.A. Blizard Sweet and bitter taste of ethanol in C57BL/6J and DBA2/J mouse strains Behav Genet 37 2007 146 159
I. Boileau, J.M. Assaad, R.O. Pihl, C. Benkelfat, M. Leyton, and M. Diksic et al. Alcohol promotes dopamine release in the human nucleus accumbens Synapse 49 2003 226 231
J.M. Boyce, and F.O. Risinger Enhancement of ethanol reward by dopamine D3 receptor blockade Brain Res 880 2000 202 206
J.M. Boyce, and F.O. Risinger Dopamine D3 receptor antagonist effects on the motivational effects of ethanol Alcohol 28 2002 47 55
C.W. Bradberry Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals Psychopharmacology (Berl) 165 2002 67 76
J. Broadbent, N.J. Grahame, and C.L. Cunningham Haloperidol prevents ethanol-stimulated locomotor activity but fails to block sensitization Psychopharmacology (Berl) 120 1995 475 482
Z.W. Brown, Z. Amit, and G.E. Rockman Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats Psychopharmacology (Berl) 64 1979 271 276
C. Brunelle, S.P. Barrett, and R.O. Pihl Relationship between the cardiac response to acute intoxication and alcohol-induced subjective effects throughout the blood alcohol concentration curve Hum Psychopharmacol 22 2007 437 443
A. Carlsson, J. Engel, and T.H. Svensson Inhibition of ethanol-induced excitation in mice and rats by α-methyl-p-tyrosine Psychopharmacologia 26 1972 307 312
J. Carrillo, E.C. Howard, M. Moten, B.D. Houck, C.L. Czachowski, and R.A. Gonzales A 3-day exposure to 10% ethanol with 10% sucrose successfully initiates ethanol self-administration Alcohol 42 2008 171 178
D.T. Chau, D. Gulic, H. Xi, R. Dawson, and A.I. Green Clozapine chronically suppresses alcohol drinking in Syrian golden hamsters Neuropharmacology 58 2010 351 356
D.T. Chau, J. Ahmed, T.T. Wang, H. Xie, R. Dawson, and A.I. Green Raclopride lessens the ability of clozapine to suppress alcohol drinking in Syrian golden hamsters Neuropharmacology 61 2011 646 652
N. Chaudhri, L.L. Sahuque, and P.H. Janak Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats Psychopharmacology (Berl) 207 2009 303 314
A.J. Christmas, and D.R. Maxwell A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats Neuropharmacology 9 1970 17 29
T.L. Chuck, P.J. McLaughlin, M.N. Arizzi-LaFrance, J.D. Salamone, and M. Correa Comparison between multiple behavioral effects of peripheral ethanol administration in rats: sedation, ataxia, and bradykinesia Life Sci 79 2006 154 161
R. Clark, and E. Polish Avoidance conditioning and alcohol consumption in rhesus monkeys Science 132 1960 223 224
C. Cohen, G. Perrault, and D.J. Sanger Evidence for the involvement of dopamine receptors in ethanol-induced hyperactivity in mice Neuropharmacology 36 1997 1099 1108
G. Colombo, R. Agabio, C. Lobina, R. Reali, G. Vacca, and G.L. Gessa Stimulation of locomotor activity by voluntarily consumed ethanol in Sardinian alcohol-preferring rats Eur J Pharmacol 357 1998 109 113
W.R. Corbin, A. Gearhardt, and K. Fromme Stimulant alcohol effects prime within session drinking behavior Psychopharmacology (Berl) 197 2008 327 337
J.C. Crabbe, N.A. Johnson, D.K. Gray, A. Kosobud, and E.R. Young Biphasic effects of ethanol on open-field activity: sensitivity and tolerance in C57BL/6N and DBA/2N mice J Comp Physiol Psychol 96 1982 440 451
J.C. Crabbe, E.R. Young, C.M. Deutsch, B.R. Tam, and A. Kosobud Mice genetically selected for differences in open-field activity after ethanol Pharmacol Biochem Behav 27 1987 577 581
H.E. Criswell, D.H. Overstreet, A.H. Rezvani, K.B. Johnson, P.E. Simson, and D.J. Knapp et al. Effects of ethanol, MK-801, and chlordiazepoxide on locomotor activity in different rat lines: dissociation of locomotor stimulation from ethanol preference Alcohol Clin Exp Res 18 1994 917 923
C.L. Cunningham Flavor and location aversions produced by ethanol Behav Neural Biol 27 1979 362 367
C.L. Cunningham Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice Psychopharmacology (Berl) 120 1995 28 41
C.L. Cunningham, D.H. Malott, S.D. Dickinson, and F.O. Risinger Haloperidol does not alter expression of ethanol-induced conditioned place preference Behav Brain Res 50 1992 1 5
C.L. Cunningham, D.R. Niehus, D.H. Malott, and L.K. Prather Genetic differences in the rewarding and activating effects of morphine and ethanol Psychopharmacology (Berl) 107 1992 385 393
C.L. Cunningham, T.L. Fidler, and K.G. Hill Animal models of alcohol's motivational effects Alcohol Res Health 24 2000 85 92
C.L. Cunningham, M.A. Howard, S.J. Gill, M. Rubinstein, M.J. Low, and D.K. Grandy Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice Pharmacol Biochem Behav 67 2000 693 699
C.L. Cunningham, N.K. Ferree, and M.A. Howard Apparatus bias and place conditioning with ethanol in mice Psychopharmacology (Berl) 170 2003 409 422
D. Davidson, K. Hutchison, C. Dagon, and R. Swift Assessing the stimulant effects of alcohol in humans Pharmacol Biochem Behav 72 2002 151 156
H. de Wit, and T.J. Phillips Do initial responses to drugs predict future use or abuse? Neurosci Biobehav Rev 36 2012 1565 1576
H. de Wit, E.H. Uhlenhuth, J. Pierri, and C.E. Johanson Individual differences in behavioral and subjective responses to alcohol Alcohol Clin Exp Res 11 1987 52 59
G. Deneau, T. Yanagita, and M.H. Seevers Self-administration of psychoactive substances by the monkey Psychopharmacologia 16 1969 30 48
G. Di Chiara, and A. Imperato Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats Proc Natl Acad Sci 85 1988 5274 5278
S.D. Dickinson, E.L. Lee, K. Rindal, and C.L. Cunningham Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice Psychopharmacology (Berl) 165 2003 238 244
V.P. Dole, and R.T. Gentry Toward an analogue of alcoholism in mice: scale factors in the model Proc Natl Acad Sci 81 1984 3543 3546
V.P. Dole, A. Ho, and R.T. Gentry Toward an analogue of alcoholism in mice: criteria for recognition of pharmacologically motivated drinking Proc Natl Acad Sci 82 1985 3469 3471
W.M. Doyon, J.L. York, L.M. Diaz, H.H. Samson, C.L. Czachowski, and R.A. Gonzales Dopamine activity in the nucleus accumbens during consummatory phases of oral ethanol self-administration Alcohol Clin Exp Res 27 2003 1573 1582
W.M. Doyon, S.K. Anders, V.S. Ramachandra, C.L. Czachowski, and R.A. Gonzales Effect of operant self-administration of 10% ethanol plus 10% sucrose on dopamine and ethanol concentrations in the nucleus accumbens J Neurochem 93 2005 1469 1481
D.J. Drobes, R.F. Anton, S.E. Thomas, and K. Voronin Effects of naltrexone and nalmefene on subjective response to alcohol among non-treatment-seeking alcoholics and social drinkers Alcohol Clin Exp Res 28 2004 1362 1370
M. El Yacoubi, C. Ledent, J.F. Ménard, M. Parmentier, J. Costentin, and J.M. Vaugeois The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors Br J Pharmacol 129 2000 1465 1473
G.I. Elmer, R.A. Meisch, and F.R. George Differential concentration-response curves for oral ethanol self-administration in C57BL/6J and BALB/cJ mice Alcohol 4 1987 63 68
G.I. Elmer, R.A. Meisch, S.R. Goldberg, and F.R. George Ethanol self-administration in long sleep and short sleep mice indicates reinforcement is not inversely related to neurosensitivity J Pharmacol Exp Ther 254 1990 1054 1062
J. Engel, U. Strömbom, T.H. Svensson, and B. Waldeck Suppression by alpha-methyltyrosine of ethanol-induced locomotor stimulation: partial reversal by l-dopa Psychopharmacologia 37 1974 275 279
J.L. Enggasser, and H. de Wit Haloperidol reduces stimulant and reinforcing effects of ethanol in social drinkers Alcohol Clin Exp Res 25 2001 1448 1456
M.A. Enoch The role of GABA(A) receptors in the development of alcoholism Pharmacol Biochem Behav 90 2008 95 104
F.R. Ervin, R.M. Palmour, S.N. Young, C. Guzman-Flores, and J. Juarez Voluntary consumption of beverage alcohol by vervet monkeys: population screening, descriptive behavior and biochemical measures Pharmacol Biochem Behav 36 1990 367 373
C.S. Ferguson, S. Miksys, R. Palmour, and R.F. Tyndale Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys Drug Metab Dispos 39 2011 2233 2241
C.S. Ferguson, S. Miksys, R.M. Palmour, and R.F. Tyndale Differential effects of nicotine treatment and ethanol self-administration on CYP2A6, CYP2B6 and nicotine pharmacokinetics in African green monkeys J Pharmacol Exp Ther 343 2012 628 637
T.L. Fidler, M.S. Powers, J.J. Ramirez, A. Crane, J. Mulgrew, and P. Smitasin et al. Dependence induced increases in intragastric alcohol consumption in mice Addict Biol 17 2012 13 32
E.W. Fish, J.F. DeBold, and K.A. Miczek Repeated alcohol: behavioral sensitization and alcohol-heightened aggression in mice Psychopharmacology (Berl) 160 2002 39 48
E.W. Fish, J.E. Robinson, M.C. Krouse, C.W. Hodge, C. Reed, and T.J. Phillips et al. Intracranial self-stimulation in FAST and SLOW mice: effects of alcohol and cocaine Psychopharmacology (Berl) 220 2012 719 730
F.L. Fitz-Gerald, M.A. Barfield, and R.J. Warrington Voluntary alcohol consumption in chimpanzees and orangutans Q J Stud Alcohol 29 1968 330 336
S.B. Flagel, and T.E. Robinson Quantifying the psychomotor activating effects of cocaine in the rat Behav Pharmacol 18 2007 297 302
P.J. Fletcher, J. Sinyard, and G.A. Higgins The effects of the 5-HT(2C) receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists Psychopharmacology (Berl) 187 2006 515 525
M.M. Ford, A.M. Fretwell, G.P. Mark, and D.A. Finn Influence of reinforcement schedule on ethanol consumption patterns in non-food restricted male C57BL/6J mice Alcohol 41 2007 21 29
O.A. Forsander Hypothesis: factors involved in the mechanisms regulating food intake affect alcohol consumption Alcohol Alcohol 29 1994 503 512
H.J. Friedman, J.A. Carpenter, D. Lester, and C.L. Randall Effect of alpha-methyl-p-tyrosine on dose-dependent mouse strain differences in locomotor activity after ethanol J Stud Alcohol 41 1980 1 7
G.D. Frye, and G.R. Breese An evaluation of the locomotor stimulating action of ethanol in rats and mice Psychopharmacology (Berl) 75 1981 372 379
G.J. Gatto, J.M. Murphy, M.B. Waller, W.J. McBride, L. Lumeng, and T.K. Li Chronic ethanol tolerance through free-choice drinking in the P line of alcohol-preferring rats Pharmacol Biochem Behav 28 1987 111 115
R. Gerlai, M. Lahav, S. Guo, and A. Rosenthal Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects Pharmacol Biochem Behav 67 2000 773 782
J.M. Gilman, V.A. Ramchandani, M.B. Davis, J.M. Bjork, and D.W. Hommer Why we like to drink: a functional magnetic resonance imaging study of the rewarding and anxiolytic effects of alcohol J Neurosci 28 2008 4583 4591
R.A. Gonzales, M.O. Job, and W.M. Doyon The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement Pharmacol Ther 103 2004 121 146
M.E. Graham, M.R. Edwards, L. Holden-Dye, A. Morgan, R.D. Burgoyne, and J.W. Barclay UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans Mol Biol Cell 20 2009 43 55
N.J. Grahame, and C.L. Cunningham Intravenous ethanol self-administration in C57BL/6J and DBA/2J mice Alcohol Clin Exp Res 21 1997 56 62
N.J. Grahame, M.J. Low, and C.L. Cunningham Intravenous self-administration of ethanol in beta-endorphin-deficient mice Alcohol Clin Exp Res 22 1998 1093 1098
K.A. Grant, and A.J. Bennett Advances in nonhuman primate alcohol abuse and alcoholism research Pharmacol Ther 100 2003 235 255
K.A. Grant, and C.E. Johanson Oral ethanol self-administration in free-feeding rhesus monkeys Alcohol Clin Exp Res 12 1988 780 784
B.F. Grant, D.A. Dawson, F.S. Stinson, S.P. Chou, M.C. Dufour, and R.P. Pickering The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002 Drug Alcohol Depend 74 2004 223 234
A.S. Green, and N.J. Grahame Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol? Alcohol 42 2008 1 11
A.I. Green, D.T. Chau, W.M. Keung, R. Dawson, R.I. Mesholam, and J.J. Schildkraut Clozapine reduces alcohol drinking in Syrian golden hamsters Psychiatry Res 128 2004 9 20
C.M. Gremel, and C.L. Cunningham Roles of the nucleus accumbens and amygdala in the acquisition and expression of ethanol-conditioned behavior in mice J Neurosci 28 2008 1076 1084
J. Guardia, A.M. Catafau, F. Batlle, J.C. Martín, L. Segura, and B. Gonzalvo et al. Striatal dopaminergic D(2) receptor density measured by [(123)I]iodobenzamide SPECT in the prediction of treatment outcome of alcohol-dependent patients Am J Psychiatry 157 2000 127 129
D.J. Guarnieri, and U. Heberlein Drosophila melanogaster, a genetic model system for alcohol research Int Rev Neurobiol 54 2003 199 228
D. Gulick, and A.I. Green Role of caloric homeostasis and reward in alcohol intake in Syrian golden hamsters Physiol Behav 101 2010 518 526
F.S. Hall, S. Huang, G.W. Fong, A. Pert, and M. Linnoila Effects of isolation-rearing on locomotion, anxiety and responses to ethanol in Fawn Hooded and Wistar rats Psychopharmacology (Berl) 139 1998 203 209
R.A. Harris, W. Krause, E. Goh, and J. Case Behavioral and biochemical effects of chronic consumption of ethanol by hamsters Pharmacol Biochem Behav 10 1979 343 347
D.S. Hasin, F.S. Stinson, E. Ogburn, and B.F. Grant Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions Arch Gen Psychiatry 64 2007 830 842
R.A. Hendler, V.A. Ramchandani, J. Gilman, and D.W. Hommer Stimulant and sedative effects of alcohol Curr Top Behav Neurosci 13 2013 489 509
J.E. Henningfield, N.A. Ator, and R.R. Griffiths Establishment and maintenance of oral ethanol self-administration in the baboon Drug Alcohol Depend 7 1981 113 124
R.D. Hienz, J.V. Brady, D.A. Bowers, and N.A. Ator Ethanol's effects on auditory thresholds and reaction times during the acquisition of chronic ethanol self-administration in baboons Drug Alcohol Depend 24 1989 213 225
C.W. Hodge, H.H. Samson, and A.M. Chappelle Alcohol self-administration: further examination of the role of dopamine receptors in the nucleus accumbens Alcohol Clin Exp Res 21 1997 1083 1091
L. Holdstock, A.C. King, and H. de Wit Subjective and objective responses to ethanol in moderate/heavy and light social drinkers Alcohol Clin Exp Res 24 2000 789 794
S.E. Holstein, L. Dobbs, and T.J. Phillips Attenuation of the stimulant response to ethanol is associated with enhanced ataxia for a GABA(A), but not a GABA(B), receptor agonist Alcohol Clin Exp Res 33 2009 108 120
S.M. Hölter, R. Landgraf, W. Zieglgänsberger, and R. Spanagel Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation Alcohol Clin Exp Res 21 1997 862 868
S.M. Hölter, A.C. Linthorst, J.M. Reul, and R. Spanagel Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats Pharmacol Biochem Behav 66 2000 143 151
A. Imperato, and G. Di Chiara Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol J Pharmacol Exp Ther 239 1986 219 228
Y. Itzhak, and J.L. Martin Blockade of alcohol-induced locomotor sensitization and conditioned place preference in DBA mice by 7-nitroindazole Brain Res 858 2000 402 407
E.T. Iwamoto An assessment of the spontaneous activity of rats administered morphine, phencyclidine, or nicotine using automated and observational methods Psychopharmacology (Berl) 84 1984 374 382
B.L. Jacobs, and P.B. Farel Motivated behaviors produced by increased arousal in the presence of goal objects Physiol Behav 6 1971 473 476
C. Jimenez-Gomez, G. Winger, R.L. Dean, D.R. Deaver, and J.H. Woods Naltrexone decreases d-amphetamine and ethanol self-administration in rhesus monkeys Behav Pharmacol 22 2011 87 90
J. Juarez, C. Guzman-Flores, F.R. Ervin, and R.M. Palmour Voluntary alcohol consumption in vervet monkeys: individual, sex, and age differences Pharmacol Biochem Behav 46 1993 985 988
A.B. Kampov-Polevoy, D.B. Matthews, L. Gause, A.L. Morrow, and D.H. Overstreet P rats develop physical dependence on alcohol via voluntary drinking: changes in seizure thresholds, anxiety, and patterns of alcohol drinking Alcohol Clin Exp Res 24 2000 278 284
K.M. Kantak, and C. Luzzo Ethanol vapor self-administration in adult C57BL/6J male mice Drug Alcohol Depend 86 2007 123 131
S.N. Katner, C.T. Flynn, S.N. Von Huben, A.J. Kirsten, S.A. Davis, and C.C. Lay et al. Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure Alcohol Clin Exp Res 28 2004 873 883
S.N. Katner, S.N. Von Huben, S.A. Davis, C.C. Lay, R.D. Crean, and A.J. Roberts et al. Robust and stable drinking behavior following long-term oral alcohol intake in rhesus macaques Drug Alcohol Depend 91 2007 236 243
K.R. Kaun, R. Azanchi, Z. Maung, J. Hirsh, and U. Heberlein A Drosophila model for alcohol reward Nat Neurosci 14 2011 612 619
B.M. Kelley, A.L. Bandy, and L.D. Middaugh A study examining intravenous ethanol-conditioned place preference in C57BL/6J mice Alcohol Clin Exp Res 21 1997 1661 1666
L.J. Kily, Y.C. Cowe, O. Hussain, S. Patel, S. McElwaine, and F.E. Cotter et al. Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways J Exp Biol 211 2008 1623 1634
A.C. King, T. Houle, H. de Wit, L. Holdstock, and A. Schuster Biphasic alcohol response differs in heavy versus light drinkers Alcohol Clin Exp Res 26 2002 827 835
A.C. King, H. de Wit, P.J. McNamara, and D. Cao Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking Arch Gen Psychiatry 68 2011 389 399
A.C. King, P.J. McNamara, D.S. Hasin, and D. Cao Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study Biol Psychiatry 2014 [in press]
U.M. Koechling, B.R. Smith, and A. Zalman Differential effects of catecholamine antagonists on ethanol-induced excitation in mice Psychopharmacology (Berl) 102 1990 234 238
M. Kornet, C. Goosen, L.G. Ribbens, and J.M. van Ree Analysis of spontaneous alcohol drinking in rhesus monkeys Physiol Behav 47 1990 679 684
E.C. Krimmer, and M.D. Schechter HAD and LAD rats respond differently to stimulating effect but not discriminative effects of ethanol Alcohol 9 1992 71 74
P.J. Kulkosky, and N.W. Cornell Free-choice ethanol intake and ethanol metabolism in the hamster and rat Pharmacol Biochem Behav 11 1979 439 444
A. Larsson, and J.A. Engel Neurochemical and behavioral studies on ethanol and nicotine interactions Neurosci Biobehav Rev 27 2004 713 720
A. Larsson, L. Svensson, B. Söderpalm, and J.A. Engel Role of different nicotinic acetylcholine receptors in mediating behavioral and neurochemical effects of ethanol in mice Alcohol 28 2002 157 167
A.D. Lê, D. Tomkins, G. Higgins, B. Quan, and E.M. Sellers Effects of 5-HT3, D1 and D2 receptor antagonists on ethanol- and cocaine-induced locomotion Pharmacol Biochem Behav 57 1997 325 332
J. Lee, C. Jee, and S.L. McIntire Ethanol preference in C. elegans Genes Brain Behav 8 2009 578 585
X. Leinekugel, I. Khalilov, H. McLean, O. Caillard, J.L. Gaiarsa, and Y. Ben-Ari et al. GABA is the principal fast-acting excitatory transmitter in the neonatal brain Adv Neurol 79 1999 189 201
C.H. Lemon, S.M. Brasser, and D.V. Smith Alcohol activates a sucrose-responsive gustatory neural pathway J Neurophysiol 92 2004 536 544
D. Lester, and E.X. Freed Criteria for an animal model of alcoholism Pharmacol Biochem Behav 1 1973 103 107
M. Leyton, S.N. Young, P. Blier, G.B. Baker, R.O. Pihl, and C. Benkelfat Acute tyrosine depletion and alcohol ingestion in healthy women Alcohol Clin Exp Res 24 2000 459 464
J.G. Linakis, and C.L. Cunningham Effects of concentration of ethanol injected intraperitoneally on taste aversion, body temperature, and activity Psychopharmacology (Berl) 64 1979 61 65
M.F. Lopez, N.J. Grahame, and H.C. Becker Development of ethanol withdrawal-related sensitization and relapse drinking in mice selected for high- or low-ethanol preference Alcohol Clin Exp Res 35 2011 953 962
W.H. Lyness, and F.L. Smith Influence of dopaminergic and serotonergic neurons on intravenous ethanol self-administration in the rat Pharmacol Biochem Behav 42 1992 187 192
A.M. Lyons, E.G. Lowery, D.R. Sparta, and T.E. Thiele Effects of food availability and administration of orexigenic and anorectic agents on elevated ethanol drinking associated with drinking in the dark procedures Alcohol Clin Exp Res 32 2008 1962 1968
N.J. Mackintosh The psychology of animal learning 1974 Academic Press London
C.S. Martin, M. Earleywine, R.E. Musty, M.W. Perrine, and R.M. Swift Development and validation of the Biphasic Alcohol Effects Scale Alcohol Clin Exp Res 17 1993 140 146
D. Martinez, R. Gil, M. Slifstein, D.R. Hwang, Y. Huang, and A. Perez et al. Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum Biol Psychiatry 58 2005 779 786
L. Martí-Prats, M.J. Sánchez-Catalán, L. Hipólito, A. Orrico, T. Zornoza, and A. Polache et al. Systemic administration of d-penicillamine prevents the locomotor activation after intra-VTA ethanol administration in rats Neurosci Lett 483 2010 143 147
D.B. Matthews, D.H. Overstreet, A.H. Rezvani, L.L. Devaud, and A.L. Morrow Effects of sweetened ethanol solutions on ethanol self-administration and blood ethanol levels Pharmacol Biochem Behav 68 2001 13 21
W.J. McBride, Z.A. Rodd, R.L. Bell, L. Lumeng, and T.K. Li The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats - animal models of alcoholism Alcohol 2014 [in press]
G.E. McClearn, and D.A. Rodgers Differences in alcohol preference among inbred strains of mice Q J Stud Alcohol 20 1959 691 695
B.A. McCool, and A.M. Chappell Using monosodium glutamate to initiate ethanol self-administration in inbred mouse strains Addict Biol 17 2012 121 131
D.E. McMillan, F.W. Ellis, G.D. Frye, and J.R. Pick Failure of signs of physical dependence to develop in hamsters after prolonged consumption of large doses of ethanol Pharmacol Biochem Behav 7 1977 55 57
B.A. McMillen, and H.L. Williams Role of taste and calories in the selection of ethanol by C57BL/6NHsd and Hsd:ICR mice Alcohol 15 1998 193 198
N.K. Mello, and J.H. Mendelson Evaluation of a polydipsia technique to induce alcohol consumption in monkeys Physiol Behav 7 1971 827 836
P.J. Meyer, C.K. Meshul, and T.J. Phillips Ethanol- and cocaine-induced locomotion are genetically related to increases in accumbal dopamine Genes Brain Behav 8 2009 346 355
G.M. Miller, J. Bendor, S. Tiefenbacher, H. Yang, M.A. Novak, and B.K. Madras A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression Mol Psychiatry 9 2004 99 108
T. Mori, J. Baba, Y. Ichimaru, and T. Suzuki Effects of rolipram, a selective inhibitor of phosphodiesterase 4, on hyperlocomotion induced by several abused drugs in mice Jpn J Pharmacol 83 2000 113 118
N.P. Murphy, H.A. Lam, Z. Chen, J.E. Pintar, and N.T. Maidment Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene Brain Res 953 2002 276 280
National Institute on Alcohol Abuse and Alcoholism Percent distribution of current drinking status, drinking levels, and heavy drinking days by sex for persons 18 years of age and older: United States, NHIS, 1997-2002 Estimates calculated by the Alcohol Epidemiologic Data System 2004 CDC National Center for Health Statistics
D.B. Newlin, and J.B. Thomson Alcohol challenge with sons of alcoholics: a critical review and analysis Psychol Bull 108 1990 383 402
L.E. O'Dell, A.J. Roberts, R.T. Smith, and G.F. Koob Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure Alcohol Clin Exp Res 28 2004 1676 1682
T. Okamoto, M.T. Harnett, and H. Morikawa Hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice J Neurophysiol 95 2006 619 626
J. Olds, and P. Milner Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain J Comp Physiol Psychol 47 1954 419 427
P. Paivarinta, and E.R. Korpi Voluntary ethanol drinking increases locomotor activity in alcohol-preferring AA rats Pharmacol Biochem Behav 44 1993 127 132
S. Palm, E. Roman, and I. Nylander Differences in voluntary ethanol consumption in Wistar rats from five different suppliers Alcohol 45 2011 607 614
R.M. Palmour, F.R. Ervin, G.B. Baker, and S.N. Young An amino acid mixture deficient in phenylalanine and tyrosine reduces cerebrospinal fluid catecholamine metabolites and alcohol consumption in vervet monkeys Psychopharmacology (Berl) 136 1998 1 7
R. Pastor, C. Sanchis-Segura, and C.M. Aragon Effect of selective antagonism of mu(1)-, mu(1/2)-, mu(3)-, and delta-opioid receptors on the locomotor-stimulating actions of ethanol Drug Alcohol Depend 78 2005 289 295
A.O. Pfeffer, and H.H. Samson Haloperidol and apomorphine effects on ethanol reinforcement in free feeding rats Pharmacol Biochem Behav 29 1988 343 350
K.M. Phillips Effects of time and administration of ethanol on open field behavior in hamsters Physiol Behav 29 1982 785 787
T.J. Phillips, and E.H. Shen Neurochemical bases of locomotion and ethanol stimulant effects Int Rev Neurobiol 39 1996 243 282
T.J. Phillips, M. Huson, C. Gwiazdon, S. Burkhart-Kasch, and E.H. Shen Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice Alcohol Clin Exp Res 19 1995 269 278
T.J. Phillips, K.J. Brown, S. Burkhart-Kasch, C.D. Wenger, M.A. Kelly, and M. Rubinstein et al. Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors Nat Neurosci 1 1998 610 615
T.J. Phillips, J. Broadbent, S. Burkhart-Kasch, C. Henderson, C.D. Wenger, and C. McMullin et al. Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion Behav Neurosci 119 2005 892 910
R.C. Pierce, and V. Kumaresan The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neurosci Biobehav Rev 30 2006 215 238
M.M. Pina, and C.L. Cunningham Effects of dopamine receptor antagonists on the acquisition of ethanol-induced conditioned place preference in mice Psychopharmacology (Berl) 231 2014 459 468
L. Pohorecky Biphasic action of ethanol Biobehav Rev 1 1977 231 244
E. Quertemont, and P. De Witte Conditioned stimulus preference after acetaldehyde but not ethanol injections Pharmacol Biochem Behav 68 2001 449 454
E. Quertemont, S. Tambour, and E. Tirelli The role of acetaldehyde in the neurobehavioral effects of ethanol: a comprehensive review of animal studies Prog Neurobiol 75 2005 247 274
M.E. Quintanilla Effect of low doses of ethanol on spontaneous locomotor activity in UChB and UChA rats Addict Biol 4 1999 443 448
M.E. Quintanilla, and L. Tampier Acetaldehyde-reinforcing effects: differences in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats Alcohol 31 2003 63 69
C. Quoilin, V. Didone, E. Tirelli, and E. Quertemont Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice Psychopharmacology (Berl) 219 2012 1165 1177
V. Ramachandra, S. Phuc, A.C. Franco, and R.A. Gonzales Ethanol preference is inversely correlated with ethanol-induced dopamine release in 2 substrains of C57BL/6 mice Alcohol Clin Exp Res 31 2007 1669 1676
V.A. Ramchandani, J. Umhau, F.J. Pavon, V. Ruiz-Velasco, W. Margas, and H. Sun et al. A genetic determinant of the striatal dopamine response to alcohol in men Mol Psychiatry 16 2011 809 817
C.L. Randall, J.A. Carpenter, D. Lester, and H.J. Friedman Ethanol-induced mouse strain differences in locomotor activity Pharmacol Biochem Behav 3 1975 533 535
S. Rassnick, L. Pulvirenti, and G.F. Koob Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens Psychopharmacology (Berl) 109 1992 92 98
S. Rassnick, L. Stinus, and G.F. Koob The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat Brain Res 623 1993 16 24
R.J. Reiter, K. Blum, J.E. Wallace, and J.H. Merritt Pineal gland: evidence for an influence on ethanol preference in male Syrian hamsters Comp Biochem Physiol 47 1974 11 16
J.S. Rhodes, K. Best, J.K. Belknap, D.A. Finn, and J.C. Crabbe Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice Physiol Behav 84 2005 53 63
J.S. Rhodes, M.M. Ford, C.H. Yu, L.L. Brown, D.A. Finn, and T. Garland Jr. et al. Mouse inbred strain differences in ethanol drinking to intoxication Genes Brain Behav 6 2007 1 18
T.L. Ripley, and D.N. Stephens Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawal Br J Pharmacol 164 2011 1335 1356
F.O. Risinger, and R.A. Oakes Dose- and conditioning trial-dependent ethanol-induced conditioned place preference in Swiss-Webster mice Pharmacol Biochem Behav 55 1996 117 123
F.O. Risinger, S.D. Dickinson, and C.L. Cunningham Haloperidol reduces ethanol-induced motor activity stimulation but not conditioned place preference Psychopharmacology (Berl) 107 1992 453 456
F.O. Risinger, D.H. Malott, L.K. Prather, D.R. Niehus, and C.L. Cunningham Motivational properties of ethanol in mice selectively bred for ethanol-induced locomotor differences Psychopharmacology (Berl) 116 1994 207 216
F.O. Risinger, P.A. Freeman, M. Rubinstein, M.J. Low, and D.K. Grandy Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice Psychopharmacology (Berl) 152 2000 343 350
Z.A. Rodd, R.L. Bell, D.L. McKinzie, A.A. Webster, J.M. Murphy, and L. Lumeng et al. Low-dose stimulatory effects of ethanol during adolescence in rat lines selectively bred for high alcohol intake Alcohol Clin Exp Res 28 2004 535 543
Z.A. Rodd, R.I. Melendez, R.L. Bell, K.A. Kuc, Y. Zhang, and J.M. Murphy et al. Intracranial self-administration of ethanol within the ventral tegmental area of male Wistar rats: evidence for involvement of dopamine neurons J Neurosci 24 2004 1050 1057
Z.A. Rodd, R.L. Bell, Y. Zhang, J.M. Murphy, A. Goldstein, and A. Zaffaroni et al. Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotonin Neuropsychopharmacology 30 2005 330 338
Z.A. Rodd-Henricks, R.L. Bell, K.A. Kuc, J.M. Murphy, W.J. McBride, and L. Lumeng et al. Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats Alcohol Clin Exp Res 25 2001 1140 1150
A. Rominger, P. Cumming, G. Xiong, G. Koller, G. Böning, and M. Wulff et al. [18F]Fallypride PET measurement of striatal and extrastriatal dopamine D 2/3 receptor availability in recently abstinent alcoholics Addict Biol 17 2012 490 503
D. Rüedi-Bettschen, J.K. Rowlett, S. Rallapalli, T. Clayton, J.M. Cook, and D.M. Platt Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys Alcohol Clin Exp Res 37 2013 624 634
S.Y. Rueger, and A.C. King Validation of the Brief Biphasic Alcohol Effects Scale (B-BAES) Alcohol Clin Exp Res 37 2013 470 476
H.H. Samson Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats Alcohol Clin Exp Res 10 1986 436 442
H.H. Samson, F.J. Files, C. Denning, and S. Marvin Comparison of alcohol-preferring and nonpreferring selectively bred rat lines. I. Ethanol initiation and limited access operant self-administration Alcohol Clin Exp Res 22 1998 2133 2146
F.P. Sanchez, L. Dickenson, and F.R. George Ethanol self-administration is genetically independent of locomotor stimulation in fast and slow mice Alcohol 13 1996 79 84
M.J. Sánchez-Catalán, L. Hipólito, T. Zornoza, A. Polache, and L. Granero Motor stimulant effects of ethanol and acetaldehyde injected into the posterior ventral tegmental area of rats: role of opioid receptors Psychopharmacology (Berl) 204 2009 641 653
B. Sanders Sensitivity to low doses of ethanol and pentobarbital in mice selected for sensitivity to hypnotic doses of ethanol J Comp Physiol Psychol 90 1976 394 398
S. Sanders, and N.E. Spear Ethanol acceptance is high during early infancy and becomes still higher after previous ethanol ingestion Alcohol Clin Exp Res 31 2007 1148 1158
M.C. Sañudo-Peña, J. Romero, G.E. Seale, J.J. Fernandez-Ruiz, and J.M. Walker Activational role of cannabinoids on movement Eur J Pharmacol 391 2000 269 274
M.A. Schuckit Ethanol-induced changes in body sway in men at high alcoholism risk Arch Gen Psychiatry 42 1985 375 379
M.L. Schwandt, C.S. Barr, S.J. Suomi, and J.D. Higley Age-dependent variation in behavior following acute ethanol administration in male and female adolescent rhesus macaques (Macaca mulatta) Alcohol Clin Exp Res 31 2007 228 237
M.L. Schwandt, J.D. Higley, S.J. Suomi, M. Heilig, and C.S. Barr Rapid tolerance and locomotor sensitization in ethanol-naïve adolescent rhesus macaques Alcohol Clin Exp Res 32 2008 1217 1228
E.H. Shen, J.C. Crabbe, and T.J. Phillips Dopamine antagonist effects on locomotor activity in naïve and ethanol-treated FAST and SLOW selected lines of mice Psychopharmacology (Berl) 118 1995 28 36
M.A. Simmons, J.L. Werkheiser, and T.J. Hudzik Acute nicotine and phencyclidine increase locomotor activity of the guinea pig with attenuated potencies relative to their effects on rat or mouse Pharmacol Biochem Behav 94 2010 410 415
J.D. Sinclair, and R.J. Senter Increased preference for ethanol in rats following deprivation Psychon Sci 8 1967 11 12
J.D. Sinden, and J. Le Magnen Parameters of low-dose ethanol intravenous self-administration in the rat Pharmacol Biochem Behav 16 1982 181 183
C.M. Singh, and U. Heberlein Genetic control of acute ethanol-induced behaviors in Drosophila Alcohol Clin Exp Res 24 2000 1127 1136
S.G. Smith, and W.M. Davis Intravenous alcohol self-administration in the rat Pharmacol Res Commun 6 1974 379 402
B. Söderpalm, and M. Ericson Neurocircuitry involved in the development of alcohol addiction: the dopamine system and its access points Curr Top Behav Neurosci 13 2013 127 161
R.B. Stewart, J.M. Murphy, W.J. McBride, L. Lumeng, and T.K. Li Place conditioning with alcohol in alcohol-preferring and -nonpreferring rats Pharmacol Biochem Behav 53 1996 487 491
S. Tambour, V. Didone, E. Tirelli, and E. Quertemont Locomotor effects of ethanol and acetaldehyde after peripheral and intraventricular injections in Swiss and C57BL/6J mice Behav Brain Res 172 2006 145 154
A. Tang, M.A. George, J.A. Randall, and R.A. Gonzales Ethanol increases extracellular dopamine concentration in the ventral striatum in C57BL/6 mice Alcohol Clin Exp Res 27 2003 1083 1089
P.K. Thanos, N.B. Taintor, S.N. Rivera, H. Umegaki, H. Ikari, and G. Roth et al. DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking Alcohol Clin Exp Res 28 2004 720 728
P.K. Thanos, S.N. Rivera, K. Weaver, D.K. Grandy, M. Rubinstein, and H. Umegaki et al. Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking Life Sci 77 2005 130 139
M.J. Thrasher, P.A. Freeman, and F.O. Risinger Clozapine's effects on ethanol's motivational properties Alcohol Clin Exp Res 23 1999 1377 1385
E. Truxell, and N.E. Spear Immediate acceptance of ethanol in infant rats: ontogenetic differences with moderate but not high ethanol concentration Alcohol Clin Exp Res 28 2004 1200 1211
E.M. Truxell, J.C. Molina, and N.E. Spear Ethanol intake in the juvenile, adolescent, and adult rat: effects of age and prior exposure to ethanol Alcohol Clin Exp Res 31 2007 755 765
N.B. Urban, L.S. Kegeles, M. Slifstein, X. Xu, D. Martinez, and E. Sakr et al. Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [ 11C]raclopride Biol Psychiatry 68 2010 689 696
G.R. Valdez, A.J. Roberts, K. Chan, H. Davis, M. Brennan, and E.P. Zorrilla et al. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor Alcohol Clin Exp Res 26 2002 1494 1501
E.J. Vallender, D. Rüedi-Bettschen, G.M. Miller, and D.M. Platt A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys Drug Alcohol Depend 109 2010 252 256
D. van der Kooy, M. O'Shaughnessy, R.F. Mucha, and H. Kalant Motivational properties of ethanol in naive rats as studied by place conditioning Pharmacol Biochem Behav 19 1983 441 445
L.J. Vanderschuren, and R.C. Pierce Sensitization processes in drug addiction Curr Top Behav Neurosci 3 2010 179 195
V. Vengeliene, A. Bilbao, A. Molander, and R. Spanagel Neuropharmacology of alcohol addiction Br J Pharmacol 154 2008 299 315
J.A. Vivian, H.L. Green, J.E. Young, L.S. Majersky, B.W. Thomas, and C.A. Shively et al. Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis), long-term characterization of sex and individual differences Alcohol Clin Exp Res 25 2001 1087 1097
S. Vlachou, and A. Markou GABAB receptors in reward processes Adv Pharmacol 58 2010 315 371
N.D. Volkow, G.J. Wang, J.S. Fowler, J. Logan, R. Hitzemann, and Y.S. Ding et al. Decreases in dopamine receptors but not in dopamine transporters in alcoholics Alcohol Clin Exp Res 20 1996 1594 1598
N.D. Volkow, G.J. Wang, L. Maynard, J.S. Fowler, B. Jayne, and F. Telang et al. Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study Psychiatry Res 116 2002 163 172
L. Vonghia, L. Leggio, A. Ferrulli, M. Bertini, G. Gasbarrini, G. Addolorato, and Alcoholism Treatment Study Group Acute alcohol intoxication Eur J Intern Med 19 2008 561 567
M.B. Waller, W.J. McBride, L. Lumeng, and T.K. Li Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats Pharmacol Biochem Behav 16 1982 501 507
M.B. Waller, W.J. McBride, G.J. Gatto, L. Lumeng, and T.K. Li Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats Science 225 1984 78 80
M.B. Waller, J.M. Murphy, W.J. McBride, L. Lumeng, and T.K. Li Effect of low dose ethanol on spontaneous motor activity in alcohol-preferring and -nonpreferring lines of rats Pharmacol Biochem Behav 24 1986 617 623
G.D. Winger, and J.H. Woods The reinforcing property of ethanol: I. Initiation, maintenance and termination of ethanol-reinforced responding Ann N Y Acad Sci 215 1973 162 175
R. Wise, and M. Bozarth A psychomotor stimulant theory of addiction Psychol Rev 94 1987 469 492
H.J. Yim, T. Schallert, P.K. Randall, and R.A. Gonzales Comparison of local and systemic ethanol effects on extracellular dopamine concentration in rat nucleus accumbens by microdialysis Alcohol Clin Exp Res 22 1998 367 374
K.K. Yoder, D.A. Kareken, R.A. Seyoum, S.J. O'connor, C. Wang, and Q.H. Zheng et al. Dopamine D(2) receptor availability is associated with subjective responses to alcohol Alcohol Clin Exp Res 29 2005 965 970
K.K. Yoder, C.C. Constantinescu, D.A. Kareken, M.D. Normandin, T.E. Cheng, and S.J. O'Connor et al. Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study Alcohol Clin Exp Res 31 2007 965 973
N. Yoneyama, J.C. Crabbe, M.M. Ford, A. Murillo, and D.A. Finn Voluntary ethanol consumption in 22 inbred mouse strains Alcohol 42 2008 149 160
E.A. Young, S.E. Dreumont, and C.L. Cunningham Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior Neurobiol Learn Mem 108 2013 28 37
Q. Zhang, Y.P. Yu, Y.L. Ye, J.T. Zhang, W.P. Zhang, and E.Q. Wei Spatiotemporal properties of locomotor activity after administration of central nervous stimulants and sedatives in mice Pharmacol Biochem Behav 97 2011 577 585
U.S. Zimmermann, I. Mick, V. Vitvitskyi, M.H. Plawecki, K.F. Mann, and S. O'Connor Development and pilot validation of computer-assisted self-infusion of ethanol (CASE): a new method to study alcohol self-administration in humans Alcohol Clin Exp Res 32 2008 1321 1328
U.S. Zimmermann, I. Mick, M. Laucht, V. Vitvitskiy, M.H. Plawecki, and K.F. Mann et al. Offspring of parents with an alcohol use disorder prefer higher levels of brain alcohol exposure in experiments involving computer-assisted self-infusion of ethanol (CASE) Psychopharmacology (Berl) 202 2009 689 697