Article (Scientific journals)
Biointerface multiparametric study of intraocular lens acrylic materials.
Bertrand, Virginie; Bozukova, Dimitriya; Svaldo Lanero, Tiziana et al.
2014In Journal of Cataract and Refractive Surgery, 40 (9), p. 1536-44
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Keywords :
Intraocular lens; biocompatibility; PCO
Abstract :
[en] PURPOSE: To compare hydrophilic and hydrophobic acrylic materials designed for intraocular lenses in a multiparametric investigation in a liquid environment to highlight their properties in terms of adhesion forces, lens epithelial cell (LEC) adhesion, and tissue response as indicators of the risk for posterior capsule opacification (PCO) development. SETTING: University of Liege, Liege, Belgium. DESIGN: Experimental study. METHODS: The hydrophobicity and surface adhesion force were assessed using contact-angle and atomic force microscopy measurements. The bioadhesiveness of the disks and the tissue response were determined by in vitro experiments using bovine serum albumin and porcine LECs and by in vivo rabbit subcutaneous implantation, respectively. RESULTS: Increasing surface hydrophobicity led to a greater surface-adhesion force and greater LEC adhesion. After 1 month, the rabbit subcutaneous implants showed a similar thin layer of fibrous capsule surrounding the disks without extensive inflammation. A layer of rounded cells in contact with disks was detected on the hydrophobic samples only. CONCLUSIONS: Hydrophobic acrylic disks that have been associated with a reduced risk for PCO in clinical studies showed increased tackiness. FINANCIAL DISCLOSURES: Proprietary or commercial disclosures are listed after the references.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Ophthalmology
Author, co-author :
Bertrand, Virginie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Bozukova, Dimitriya;  PhysIOL
Svaldo Lanero, Tiziana;  Université de Liège - ULiège > Département de Chimie > NanoChemistry and Molecular Systems Laboratory
Huang, Yi-Shiang ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Schol, Daureen
Rosière, Nancy ;  Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)
Grauwels, Magda ;  Université de Liège - ULiège > Clinique des grands animaux (chirurgie)
Duwez, Anne-Sophie  ;  Université de Liège - ULiège > Département de chimie (sciences) > Nanochimie et systèmes moléculaires
Jérôme, Christine  ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie des macromolécules et des matériaux organiques (CERM)
Pagnoulle, Christophe;  PhysIOL sa
De Pauw, Edwin  ;  Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)
De Pauw-Gillet, Marie-Claire ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Language :
English
Title :
Biointerface multiparametric study of intraocular lens acrylic materials.
Publication date :
2014
Journal title :
Journal of Cataract and Refractive Surgery
ISSN :
0886-3350
eISSN :
1873-4502
Publisher :
Elsevier, Netherlands
Volume :
40
Issue :
9
Pages :
1536-44
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2014 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
Available on ORBi :
since 06 October 2014

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