Fluorodeoxyglucose positron emission tomography and somatostatin receptor scintigraphy for diagnosing and staging carcinoid tumours: correlations with the pathological indexes p53 and Ki-67
[en] We performed this study in order to evaluate the diagnostic accuracy of whole-body fluorodeoxyglucose positron emission tomography (FDG PET) imaging and somatostatin receptor scintigraphy (SRS) for localizing primary carcinoid tumours and evaluating the extent of the disease. A secondary aim was to correlate those findings with the histological characteristics of the lesions. FDG PET was performed in 17 patients and SRS in 16. All patients had pathologically proven carcinoids. All lesions were verified by histopathological analysis or by follow-up. Ki-67 and p53 expression were assessed as an indicator of the tumours' aggressiveness. FDG PET correctly identified 4/7 primary tumours and 8/11 metastatic spreads, as compared to six and 10 respectively, for SRS. Most tumours were typical carcinoids with low Ki-67 expression. No correlation was found between the histological features and the tracer's uptake. We conclude that SRS remains the modality of choice for evaluating patients with carcinoid tumours, regardless of their proliferative activity. FDG PET should be reserved to patients with negative results on SRS. ((C) 2002 Lippincott Williams Wilkins).
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Belhocine, Tarik
Willems, Jacqueline ; Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Rigo, Pierre ; Université de Liège - ULiège > Département des sciences de la motricité > Pathologie générale et médecine nucléaire
Najjar, Fadi
Thiry, Albert ; Université de Liège - ULiège > Anatomie pathologique
Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Hustinx, Roland ; Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
Language :
English
Title :
Fluorodeoxyglucose positron emission tomography and somatostatin receptor scintigraphy for diagnosing and staging carcinoid tumours: correlations with the pathological indexes p53 and Ki-67
Publication date :
August 2002
Journal title :
Nuclear Medicine Communications
ISSN :
0143-3636
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Kulke M.H., Mayer R.J. (1999) Carcinoid tumors. N Engl J Med 340:858-868.
Kwekkeboom D.J., Krenning E.P. (1996) Somatostatin receptor scintigraphy in patients with carcinoid tumors. World J Surg 20:157-161.
Warburg O. (1956) On the origin of cancer cells. Science 123:309-314.
Pauwels E.K.J., Ribeiro M.J., Stoot J.H.M.B. (1998) FDG accumulation and tumor biology. Nucl Med Biol 25:317-322.
Delbeke D. (1999) Oncological applications of FDG PET imaging. J Nucl Med 40:1706-1715.
Vesselle H., Schmidt R.A., Pugsley J.M. (2000) Lung cancer proliferation correlates with [F-18]fluorodeoxyglucose uptake by positron emission tomography. Clin Cancer Res 6:3837-3844.
Foley A.L., Lyles R.H., Sprouse J.T., Conrad E.U. III, Eary J.F. (2000) [F-18] fluorodeoxyglucose positron emission tomography as a predictor of pathologic grade and other prognostic variables in bone and soft tissue sarcoma. Clin Cancer Res 6:1279-1287.
Higashi K., Ueda Y., Ayabe K. (2000) FDG PET in the evaluation of the aggressiveness of pulmonary adenocarcinoma: Correlation with histopathological features. Nucl Med Commun 21:707-714.
Jacob R., Welkoborsky H.J., Mann W.J., Jauch M., Amedee R. (2001) [Fluorine-18]fluorodeoxyglucose positron emission tomography, DNA ploidy and growth fraction in squamous-cell carcinomas of the head and neck. ORL J Otorhinolaryngol Relat Spec 63:307-313.
Williams E.D., Sandler M. (1963) The classification of carcinoid tumours. Lancet 1:238-239.
Krenning E.P., Kwekkeboom D.J., Bakker W.H. (1993) Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]- and [123I-Tyr3]-octreotide: The Rotterdam experience with more than 1000 patients. Eur J Nucl Med 20:716-731.
Westlin J.E., Janson E.T., Arnberg H. (1993) Somatostatin receptor scintigraphy of carcinoid tumours using the [111In-DTPA-D-Phe1]-octreotide. Acta Oncol 32:783-786.
Hammond P.J., Arka A., Peters A.M. (1994) Localization of metastatic gastroenteropancreatic tumours by somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]-octreotide. Q J Med 87:83-88.
Modlin I.M., Cornelius E., Lawton G.P. (1995) Use of an isotopic somatostatin receptor probe to image gut endocrine tumors. Arch Surg 130:367-373.
Ahlman H., Wangberg B., Tisell L.E. (1994) Clinical efficacy of octreotide scintigraphy in patients with midgut carcinoid tumours and evaluation of intraoperative scintillation detection. Br J Surg 81:1144-1149.
Gibril F., Reynolds J.C., Lubensky A. (2000) Ability of somatostatin receptor scintigraphy to identify patients with gastric carcinoids: A prospective study. J Nucl Med 41:1646-1656.
Chatal J.F., Le Bolic M.F., Kraeber-Bodere F., Rousseau C., Resche I. (2000) Nuclear medicine applications for neuroendocrine tumors. World J Surg 24:1285-1289.
Chiti A., Fanti S., Savelli G. (1998) Comparison of somatostatin receptor imaging, computed tomography and ultrasound in the clinical management of neuroendocrine gastro-enteropancreatic tumours. Eur J Nucl Med 25:1396-1403.
Adams S., Baum R., Rink T. (1998) Limited value of fluorine-18 fluorodeoxyglucose positron emission tomography for the imaging of neuroendocrine tumours. Eur J Nucl Med 25:79-83.
Erasmus J.J., McAdams H.P., Patz E.F. Jr. (1998) Evaluation of primary pulmonary carcinoid tumors using FDG PET. Am J Roentgenol 170:1369-1373.
Pasquali C., Rubello D., Sperti C. (1998) Neuroendocrine tumor imaging: Can 18F-fluorodeoxyglucose positron emission tomography detect tumors with poor prognosis and aggressive behavior?. World J Surg 22:588-592.
Guinebretiere J.M., Sabourin J.C. (1997) Ki-67, marker of proliferation. Ann Pathol 17:25-30.
Martin A. (1995) The tumor suppressor gene p53 (part one). Structure, function and mechanisms of inactivation. Ann Pathol 15:178-183.
Al-Khafaji B., Noffsinger A.E., Miller M.A., DeVoe G., Stemmermann G.N., Fenoglio-Preiser C. (1998) Immunohistologic analysis of gastrointestinal and pulmonary carcinoid tumors. Hum Pathol 29:992-999.