Endocrine and social regulation of adult neurogenesis in songbirds.

[en] The identification of pronounced seasonal changes in the volume of avian song control nuclei stimulated the discovery of adult neurogenesis in songbirds as well as renewed studies in mammals including humans. Neurogenesis in songbirds is modulated by testosterone and other factors such as photoperiod, singing activity and social environment. Adult neurogenesis has been widely studied by labeling, with tritiated thymidine or its analog BrdU, cells duplicating their DNA in anticipation of their last mitotic division and following their fate as new neurons. New methods based on endogenous markers of cell cycling or of various stages of neuronal life have allowed for additional progress. In particular immunocytochemical visualization of the microtubule-associated protein doublecortin has provided an integrated view of neuronal replacement in the song control nucleus HVC. Multiple questions remain however concerning the specific steps in the neuronal life cycle that are modulated by various factors and the underlying cellular mechanisms.

Disciplines :

Neurosciences & behavior

Author, co-author :

Balthazart, Jacques ; Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Ball, Gregory F.

Language :

English

Title :

Endocrine and social regulation of adult neurogenesis in songbirds.

Publication date :

2016

Journal title :

Frontiers in Neuroendocrinology

ISSN :

0091-3022

eISSN :

1095-6808

Publisher :

Elsevier, Atlanta, United States - Florida

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 13 April 2016

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