Article (Scientific journals)
Minimal residual disease quantification by PCR in childhood acute lymphoblastic leukemia
Van der Straeten, J.; De Moerloose, B.; DRESSE, Marie-Françoise et al.
2014In Belgian Journal of Hematology, 5, p. 81-88
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Keywords :
acute Iymphoblastic leukaemia (ALL); allele speciflc oligonucleotlde (ASO); Genescan; minimal resldual disease (MRD)
Abstract :
[en] ln Belgium approximately 70 children are diagnosed with acute Iymphoblastic leukaemia annually. For these children, the monitoring of minimal residual disease has an important prognostic value. The level of minimal residual disease during the first three months of therapy is used to recognise subgroups that differ substantially in outcome. Two techniques are used for minimal residual disease monitoring: the Genescan method and the allele specifie oligonucleotide polymerase chain reaction. The Genescan method is a less sensitive method (10-3) but is fast and less expensive. The allele specifie oligonucleotide polymerase chain reaction requires more time and budget but has a sensitivity of 10-4-10-5• Both techniques have proven their value in minimal residual disease monitoring in childhood acute Iymphoblastic leukaemia.
Disciplines :
Pediatrics
Author, co-author :
Van der Straeten, J.
De Moerloose, B.
DRESSE, Marie-Françoise ;  Centre Hospitalier Universitaire de Liège - CHU > Service de pédiatrie (CHR)
Dupont, S.
Ferster, A.
Philippet, P.
Uyttebroeck, A.
van der Werff ten Bosch, J.
Demanet, C.
Bakkus, M.
Language :
English
Title :
Minimal residual disease quantification by PCR in childhood acute lymphoblastic leukemia
Publication date :
2014
Journal title :
Belgian Journal of Hematology
ISSN :
2033-3749
Publisher :
Ariez Medical Publishing, Amsterdam, Netherlands
Volume :
5
Pages :
81-88
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 May 2016

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