Article (Scientific journals)
Multimodal evoked potentials for functional quantification and prognosis in multiple sclerosis
GIFFROY, Xavier; MAES, Nathalie; Albert, Adelin et al.
2016In BMC Neurology
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Keywords :
Evoked potentials; Multiple sclerosis; Prognosis; Disability
Abstract :
[en] Functional biomarkers able to identify multiple sclerosis (MS) patients at high risk of fast disability progression are lacking. The aim of this study was to evaluate the ability of multimodal (upper and lower limbs motor, visual, lower limbs somatosensory) evoked potentials (EP) to monitor disease course and identify patients exposed to unfavourable evolution. One hundred MS patients were assessed with visual, somatosensory and motor EP and rated on the Expanded Disability Status Scale (EDSS) at baseline (T0) and about 6 years later (T1). The Spearman correlation (rS) was used to evaluate the relationship between conventional EP scores and clinical findings. Multiple (logistic) regression analysis estimated the predictive value of baseline electrophysiological data for three clinical outcomes: EDSS, annual EDSS progression, and the risk of EDSS worsening. In contrast to longitudinal correlations, cross-sectional correlations between the different EP scores and EDSS were all significant (0.33 ≤ rS < 0.67, p < 0.001). Baseline global EP score and EDSS were highly significant predictors (p < 0.0001) of EDSS progression 6 years later. The aseline global EP score was found to be an independent predictor of the EDSS annual progression rate (p < 0.001), and of the risk of disability progression over time (p < 0.005). Based on a ROC curve determination, we defined a Global EP Score cut off point (17/30) to identify patients at high risk of disability progression illustrated by a positive predictive value of 70 %. This study provides a proof of the concept that electrophysiology could be added to MRI and used as another complementary prognostic tool in MS patients.
Disciplines :
Neurology
Author, co-author :
GIFFROY, Xavier ;  Centre Hospitalier Universitaire de Liège - CHU > Service de médecine de l'appareil locomoteur
MAES, Nathalie ;  Centre Hospitalier Universitaire de Liège - CHU > Service des informations médico économiques (SIME)
Albert, Adelin  ;  Université de Liège > Département des sciences de la santé publique > Département des sciences de la santé publique
MAQUET, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie
CRIELAARD, Jean-Michel ;  Centre Hospitalier Universitaire de Liège - CHU > Service de médecine de l'appareil locomoteur
DIVE, Dominique ;  Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie
Language :
English
Title :
Multimodal evoked potentials for functional quantification and prognosis in multiple sclerosis
Publication date :
01 June 2016
Journal title :
BMC Neurology
eISSN :
1471-2377
Publisher :
BioMed Central
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 June 2016

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