Article (Scientific journals)
Peanut-allergic patients in the MIRABEL survey: characteristics, allergists' dietary advice and lessons from real life
Deschildre, A; Elegbédé, CF; Just, J et al.
2016In Clinical and Experimental Allergy, 46 (4), p. 610-20
Peer Reviewed verified by ORBi
 

Files


Full Text
Peanut-allergic patients in the MIRABEL survey - characteristics, allergists’ dietary advice and lessons from real life.pdf
Publisher postprint (201.49 kB)
Request a copy
Annexes
Peanut-allergic patients in the MIRABEL survey Tables SI and SII.docx
(34.38 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
diet; peanut allergy; real life; risk factor; severe reactions
Abstract :
[en] Background The MIRABEL survey is an observational study on peanut allergy in France, Belgium and Luxemburg. The objectives are to provide data on a large population, to analyse the consumer behaviour, to study the presence of peanut traces in pre-packed foods with/without precautionary allergen labelling (PAL), and to combine these data to quantify allergic risk and produce a cost/benefit analysis. This paper reports a real-life observatory of 785 patients (< 16y: 86%): medical characteristics, eliciting doses (ED) in real life and in oral food challenges (OFC), factors associated with severe reactions, allergist dietary advice and patients’ anxiety regarding their allergy. Methods Age and symptoms at diagnosis, route of exposure, comorbidities, allergy tests, ED (OFC/real life; mg peanut protein), dietary advice about PAL, and anxiety score were recorded. Results Median age was 3 years; 85% were declared allergic. Severe/potentially severe reactions were reported in 30% of the allergic patients: serious systemic reaction (15%), laryngeal angioedema (8%), shock (4%) and acute asthma (3%); 66% had atopic dermatitis, 58% asthma. Median ara h 2 sIgE level was 11.5 kUA/L. Of the 278 OFCs, 225 were positive (median ED: 67.3 mg). Real-life ED was < 100 mg in 44.3%. Severe reactions were significantly more frequent in teenagers and adults (P = 0.004), asthmatic patients (P = 0.033), and patients who reacted to inhalation (P < 0.001). No significant association was found for OFC ED or ara h 2 sIgE. Factors associated with strict avoidance advice including PAL were OFC ED < 100 mg (P < 0.001), but not severe reaction history (P = 0.051) or asthma (P = 0.34). Anxiety was significantly associated with strict avoidance (P < 0.001). Conclusion and clinical relevance Severe/potentially severe reactions, allergic comorbidities, and low EDs in real life are frequent in peanut-allergic patients. Asthma, teenage/ adulthood and reaction to inhalation are associated with severe symptoms. PAL and criteria guiding dietary advice need to be improved.
Disciplines :
Endocrinology, metabolism & nutrition
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Deschildre, A
Elegbédé, CF
Just, J
Bruyère, Olivier  ;  Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Van der Brempt, X
Papadopoulos, A
Beaudouin, E
Renaudin, JM
Crepet, A
Moneret-Vautrin, DA
Language :
English
Title :
Peanut-allergic patients in the MIRABEL survey: characteristics, allergists' dietary advice and lessons from real life
Publication date :
April 2016
Journal title :
Clinical and Experimental Allergy
ISSN :
0954-7894
eISSN :
1365-2222
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
46
Issue :
4
Pages :
610-20
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 September 2016

Statistics


Number of views
102 (1 by ULiège)
Number of downloads
1 (0 by ULiège)

Scopus citations®
 
68
Scopus citations®
without self-citations
50
OpenCitations
 
74

Bibliography


Similar publications



Contact ORBi