Article (Scientific journals)
Early exposure to Aroclor 1254 in vivo disrupts the functional synaptic development of newborn hippocampal granule cells.
Parent, Anne-Simone; Pinson, Anneline; Woods, N. et al.
2016In European Journal of Neuroscience, 44 (12), p. 3001-3010
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Keywords :
PCBs; critical period; hippocampus; neurogenesis; synapse formation
Abstract :
[en] Neurogenesis in the dentate gyrus is sensitive to endogenous and exogenous factors that influence hippocampal function. Ongoing neurogenesis and the integration of these new neurons throughout life thus may provide a sensitive indicator of environmental stress. We examined the effects of Aroclor 1254 (A1254), a mixture of polychlorinated biphenyls (PCBs), on the development and function of newly generated dentate granule cells. Early exposure to A1254 has been associated with learning impairment in children, suggesting potential impact on the development of hippocampus and/or cortical circuits. Oral A1254 (from the 6th day of gestation to postnatal day 21) produced the expected increase in PCB levels in brain at postnatal day 21, which persisted at lower levels into adulthood. A1254 did not affect the proliferation or survival of newborn neurons in immature animals nor did it cause overt changes in neuronal morphology. However, A1254 occluded the normal developmental increase in sEPSC frequency in the third post-mitotic week without altering the average sEPSC amplitude. Our results suggest that early exposure to PCBs can disrupt excitatory synaptic function during a period of active synaptogenesis, and thus could contribute to the cognitive effects noted in children exposed to PCBs.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Endocrinology, metabolism & nutrition
Pediatrics
Author, co-author :
Parent, Anne-Simone ;  Université de Liège > Département des sciences cliniques > Pédiatrie
Pinson, Anneline ;  Université de Liège > Département des sciences cliniques > Pédiatrie
Woods, N.
Chatzi, C.
Vaaga, C. E.
Bensen, A.
Gerard, A.
Thomé, Jean-Pierre ;  Université de Liège > Département de Biologie, Ecologie et Evolution > Ecologie animale et écotoxicologie
Bourguignon, Jean-Pierre ;  Université de Liège > Département des sciences cliniques > Département des sciences cliniques
Westbrook, G. L.
Language :
English
Title :
Early exposure to Aroclor 1254 in vivo disrupts the functional synaptic development of newborn hippocampal granule cells.
Publication date :
December 2016
Journal title :
European Journal of Neuroscience
ISSN :
0953-816X
eISSN :
1460-9568
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
44
Issue :
12
Pages :
3001-3010
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
Available on ORBi :
since 20 January 2017

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