(+) or (-)-1-(9-fluorenyl)ethyl chloroformate as chiral derivatizing agent: A review.

[en] Over the last 30years, (+/-)-1-(9-fluorenyl)ethyl chloroformate ((+/-)-FLEC) was used as a chiral derivatizing agent in various analytical applications involving a wide range of endogenous, pharmaceutical and environmentally relevant molecules. This comprehensive review aims to present all the significant aspects related to the state of the art in FLEC labeling and subsequent chiral separation of the resulting diastereomers using LC, SFC and CE techniques.

Research center :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Moldovan, Radu-Cristian

Bodoki, Ede

Servais, Anne-Catherine ; Université de Liège > Département de pharmacie > Analyse des médicaments

Crommen, Jacques ; Université de Liège > Département de pharmacie > Département de pharmacie

Oprean, Radu

Fillet, Marianne ; Université de Liège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

(+) or (-)-1-(9-fluorenyl)ethyl chloroformate as chiral derivatizing agent: A review.

Publication date :

2017

Journal title :

Journal of Chromatography. A

ISSN :

0021-9673

eISSN :

1873-3778

Publisher :

Elsevier, Amsterdam, Netherlands

Volume :

1513

Pages :

1-17

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 17 August 2017

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98 (9 by ULiège)

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