Surface EEG-Transcranial direct current stimulation (tDCS) closed-loop system

EEG algorithm; EEG-tDCS closed-loop system; Brain; Frequency bands; Brain activity; Clinical application; Cognitive task; Crossover design; Electrical current; Healthy volunteers; On-line analysis; Proof of concept; Closed loop systems

Abstract :

[en] Conventional transcranial direct current stimulation (tDCS) protocols rely on applying electrical current at a fixed intensity and duration without using surrogate markers to direct the interventions. This has led to some mixed results; especially because tDCS induced effects may vary depending on the ongoing level of brain activity. Therefore, the objective of this preliminary study was to assess the feasibility of an EEG-triggered tDCS system based on EEG online analysis of its frequency bands. Six healthy volunteers were randomized to participate in a double-blind sham-controlled crossover design to receive a single session of 10min 2mA cathodal and sham tDCS. tDCS trigger controller was based upon an algorithm designed to detect an increase in the relative beta power of more than 200%, accompanied by a decrease of 50% or more in the relative alpha power, based on baseline EEG recordings. EEG-tDCS closed-loop-system was able to detect the predefined EEG magnitude deviation and successfully triggered the stimulation in all participants. This preliminary study represents a proof-of-concept for the development of an EEG-tDCS closed-loop system in humans. We discuss and review here different methods of closed loop system that can be considered and potential clinical applications of such system. © 2017 World Scientific Publishing Company.

Disciplines :

Neurology

Author, co-author :

Leite, J.; Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States, Neuropsychophysiology Laboratory, CIPsi, School of Psychology, Braga, Portugal

Morales-Quezada, L.; Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States

Carvalho, S.; Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States, Neuropsychophysiology Laboratory, CIPsi, School of Psychology, Braga, Portugal

Thibaut, Aurore ; Université de Liège - ULiège > GIGA : Coma Group

Doruk, D.; Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States

Chen, C.-F.; Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States, Engineering Science, Loyola University Chicago, Chicago, United States

Schachter, S. C.; Center for Integration of Medicine and Innovative Technology, Harvard Medical School, Boston, United States

Rotenberg, A.; Neuromodulation Program, Division of Epilepsy and Clinical Neurophysiology and the F.M. Kirby Neurobiology Center, Department of Neurology, Boston, United States

Fregni, F.; Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States

Language :

English

Title :

Surface EEG-Transcranial direct current stimulation (tDCS) closed-loop system

Publication date :

2017

Journal title :

International Journal of Neural Systems

ISSN :

0129-0657

Publisher :

World Scientific Publishing Co. Pte Ltd

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 September 2018

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