Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie - Embryologie
Kecha, Ouafae
Brilot, Fabienne
Renard, Chantal
Martens, Henri ; Université de Liège - ULiège > Centre d'immunologie
Language :
English
Title :
The thymic repertoire of neuroendocrine-related self-antigens: Biological role in T-cell selection and pharmacological implications
Publication date :
1999
Main work title :
Neuroendocrine Control of the Thymus
Editor :
Savino, Wilson
Publisher :
Karger, Basel, Switzerland
ISBN/EAN :
3-8055-6769-3
Pages :
115-125
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] JDRF - Juvenile Diabetes Research Foundation [CA] FRSM - Fonds de la Recherche Scientifique Médicale [BE] Fondation contre le Cancer [BE] Fonds Léon Fredericq [BE] Télévie [BE]
Miller, J.F.A.P., Immunological function of the thymus (1961) Lancet, 2, pp. 748-749
Geenen, V., Kroemer, G., Multiple ways to cellular immune tolerance (1993) Immunol Today, 14, pp. 573-575
Dustin, M.L., Springer, T.A., Role of lymphocyte adhesion receptors in transient interactions and cell locomotion (1991) Annu Rev Immunol, 9, pp. 27-66
Ritter, M.A., Rozing, J., Schuurman, H.J., The true function of the thymus? (1988) Immunol Today, 9, pp. 189-193
MacDonald, H.R., Glasebrook, A.L., Schneider, R., Lees, R.L., Pircher, H., Pedrazzini, T., Kanagawa, O., Hengartner, H., T cell reactivity and tolerance to Mlsα-encoded antigens (1989) Immunol Rev, 107, pp. 89-108
Von Boehmer, H., The developmental biology of T lymphocytes (1989) Annu Rev Immunol, 6, pp. 309-326
Sprent, J., Webb, S., Can self/nonself discrimination be explained entirely by clonal deletion? (1992) Res Immunol, 143, pp. 285-287
Hogquist, K.A., Jameson, S.C., Bevan, M.J., The ligand for positive selection of T lymphocytes in the thymus (1994) Curr Opin Immunol, 6, pp. 273-278
Von Boehmer, H., Thymic selection: A matter of life and death (1992) Immunol Today, 13, pp. 454-458
Sprent, J., Tough, D.T., Lymphocyte life-span and memory (1994) Science, 265, pp. 1395-1400
Ashton-Rickardt, P.G., Tonegawa, S., A differential avidity model for T-cell selection (1994) Immunol Today, 15, pp. 362-366
Sebzda, E., Wallace, V.A., Mayer, J., Young, R.S.M., Mak, T., Ohashi, P.S., Positive and negative thymocyte selection induced by different concentrations of a single peptide (1994) Science, 263, pp. 1615-1618
Allen, P.M., Peptides in positive and negative selection: A delicate balance (1994) Cell, 76, pp. 593-596
Ott, I., Scott, J.C., The galactogogue action of the thymus and corpus luteum (1910) Proc Soc Exp Biol Med, 8, p. 49
Geenen, V., Legros, J.J., Franchimont, P., Baudrihaye, M., Defresne, M.P., Boniver, J., The neuroendocrine thymus: Coexistence of oxytocin and neurophysin in the human thymus (1986) Science, 232, pp. 508-511
Markwick, A.J., Lolait, S.J., Funder, J.W., Immunoreactive arginine vasopressin in the rat thymus (1986) Endocrinology, 119, pp. 1060-1064
Geenen, V., Legros, J.J., Franchimont, P., Defresne, M.P., Boniver, J., Ivell, R., Richter, D., The thymus as a neuroendocrine organ. Synthesis of vasopressin and oxytocin in human thymic epithelium (1987) Ann NY Acad Sci, 496, pp. 56-66
Moll, U.M., Lane, B.L., Robert, F., Geenen, V., Legros, J.J., The neuroendocrine thymus. Abundant occurrence of oxytocin-, vasopressin-, and neurophysin-like peptides in epithelial cells (1988) Histochemistry, 89, pp. 385-390
Argiolas, A., Gessa, G.L., Melis, M.R., Stancampiano, R., Vaccari, A., Effects of neonatal and adult thyroid dysfunction on thymic oxytocin (1990) Neuroendocrinology, 52, pp. 556-559
Robert, F., Geenen, V., Schoenen, J., Burgeon, E., De Groote, D., Defresne, M.P., Legros, J.J., Franchimont, P., Colocalization of immunoreactive oxytocin, vasopressin and interleukin-1 in human thymic epithelial neuroendocrine cells (1991) Brain Behav Immun, 5, pp. 102-115
Geenen, V., Robert, F., Martens, H., Benhida, A., Degiovanni, G., Defresne, M.P., Boniver, J., Franchimont, P., At the cutting edge. Biosynthesis and paracrine/cryptocrine actions of 'self neurohypophysial-related peptides in the thymus (1991) Mol Cell Endocrinol, 76, pp. C27-C31
Milan, J., Barbijeri, M., Kovacevic, D., Arambasic, M., Kartaljevic, G., Natalic, D., Pazin, S., Identification of neuroendocrine oxytocic activity of the human fetal thymus (1990) Thymus, 15, pp. 181-185
Geenen, V., Defresne, M.P., Robert, F., Legros, J.J., Franchimont, P., Boniver, J., The neurohormonal thymic microenvironment: Immunocytochemical evidence that thymic nurse cells are neuroendocrine cells (1988) Neuroendocrinology, 47, pp. 365-368
Geenen, V., Vandersmissen, E., Martens, H., Goxe, B., Kecha, O., Legros, J.J., Lefèbvre, P.J., Martial, J.A., Cellular and molecular aspects of thymic T-cell education to neurohypophysial principles (1995) Neurohypophysis: Recent Progress of Vasopressin and Oxytocin Research, pp. 309-319. , Saito T, Kurokawa K, Yoshida S (eds): Amsterdam, Elsevier
Wiemann, M., Ehret, G., Subcellular localization of immunoreactive oxytocin within thymic epithelial cells of the male mouse (1993) Cell Tissue Res, 273, pp. 79-87
Kumamoto, K., Matsuura, T., Amagai, T., Kawata, M., Oxytocin-producing and vasopressin-producing eosinophils in the mouse spleen: Immunohistochemical, immuno-electron-microscopic and in situ hybridization studies (1995) Cell Tissue Res, 281, pp. 1-10
Webb, S.R., Spent, J., Tolerogenicity of thymic epithelium (1990) Eur J Immunol, 20, pp. 2525-2528
Lorenz, R.G., Allen, P.M., Thymic cortical epithelial cells can present self-antigens in vivo (1989) Nature, 337, pp. 560-562
Geenen, V., Vandersmissen, E., Cormann-Goffin, N., Martens, H., Legros, J.J., Degiovanni, G., Benhida, A., Franchimont, P., Membrane translocation and relationship with MHC class I of a human thymic neurophysin-like protein (1993) Thymus, 22, pp. 55-66
Rosenbaum, L.C., Neuwelt, E.A., Van Tol, H.H.M., Peng Loh, Y., Verbalis, J., Hellström, I., Hellström, K.E., Nilaver, G., Expression of neurophysin-related precursor in cell membranes of a small-cell lung carcinoma (1990) Proc Natl Acad Sci USA, 87, pp. 9928-9932
North, W.G., Yu, X., Forms of neurohypophysial peptides generated by tumors, and factors regulating their expression (1993) Regul Pept, 45, pp. 209-216
Griffin, G.H., Alazard, R., Cohen, P., Complex formation between bovine neurophysin-1 and oxytocin, vasopressin and tripeptide analogs of their NH2-terminal region (1973) J Biol Chem, 248, pp. 7975-7978
Maryanski, J.L., Romero, P., Van Pel, A., Boon, T., Salemme, F.R., Cerrottini, J.C., Corradin, G., The identification of tyrosine as a common key residue in unrelated H-2Kd restricted antigenic peptides (1991) Int Immunol, 3, pp. 1035-1042
Martens, H., Malgrance, B., Robert, F., Charlet, C., De Groote, D., Heymann, D., Godard, A., Geenen, V., Cytokine production by human thymic epithelial cells: Control by the immune recognition of the neurohypophysial self-antigen (1996) Regul Pept, 67, pp. 39-45
Elands, J., Resink, A., De Kloet, E.R., Oxytocin receptors in the rat thymic gland (1988) Eur J Pharmacol, 151, pp. 345-351
Elands, J., Resink, A., De Kloet, E.R., Neurohypophysial hormone receptors in the rat thymus, spleen and lymphocytes (1990) Endocrinology, 126, pp. 2703-2710
Martens, H., Robert, F., Legros, J.J., Geenen, V., Franchimont, P., Expression of functional neurohypophysial peptide receptors by immature and cytotoxic T-cell lines (1992) Prog Neuroendocrinimmunol, 5, pp. 31-39
Torres, B.A., Johnson, H.M., Arginine vasopressin (AVP) replacement of helper cell requirement in IFNg production. Evidence for a novel AVP receptor on mouse lymphocytes (1988) J Immunol, 81, pp. 132-136
Caldwell, J.D., Walker, C.A., Noonan, L.R., Jirikowski, G.F., Peterson, G., Pedersen, C.A., Mason, G.A., Changes in thymic oxytocin receptors during early development and in steroid-treated adult rats (1991) Prog NeuroendocrinImmunol, 4, pp. 223-233
Lolait, S.J., O'Carroll, A.M., Mahan, L.C., Felder, C.C., Button, D.C., Young III, W.S., Mezey, E., Brownstein, M.J., Extrapituitary expression of the rat V1b vasopressin receptor gene (1995) Proc Natl Acad Sci USA, 92, pp. 6783-6787
Whitfield, J.F., Perris, A.D., Youdale, T., The calcium-mediated promotion of mitotic activity in rat thymocyte populations by growth hormone, neurohormones, parathyroid hormone and prolactin (1969) J Cell Physiol, 73, pp. 203-209
Goren, H.J., Okabe, T., Lederis, K., Hollenberg, M.D., Oxytocin stimulates glucose oxidation in rat thymocytes (1984) Proc West Pharmacol Soc, 27, p. 461
Martens, H., Kecha, O., Charlet-Renard, C., Defresne, M.P., Geenen, V., Neurohypophysial peptides stimulate the phosphorylation of pre-T cells focal adhesion kinases (1998) Neuroendocrinology, 67, pp. 282-289
Geenen, V., Martens, H., Robert, F., Vrindts-Gevaert, Y., De Groote, D., Franchimont, P., Immunomodulatory properties of cyclic hexapeptide oxytocin antagonists (1992) Thymus, 20, pp. 217-226
Sundler, F., Carraway, R.E., Hakanson, R., Alumets, J., Dubois, M.P., Immunoreactive neurotensin and somatostatin in the chicken thymus. A chemical and histochemical study (1978) Cell Tissue Res, 194, pp. 367-376
Vanneste, Y., Ntodou Thome, A., Vandersmissen, E., Charlet, C., Franchimont, D., Martens, H., Lhiaubet, A.M., Geenen, V., Identification of neurotensin-related peptides in human thymic epithelial cell membranes and relationship with major histocompatibilty complex class I molecules (1997) J Neuroimmunol, 76, pp. 161-166
Ericsson, A., Geenen, V., Robert, F., Legros, J.J., Vrindts-Gevaert, Y., Franchimont, P., Brene, S., Persson, H., Expression of preprotachykinin A and neuropeptide-Y messenger RNA in the thymus (1990) Mol Endocrinol, 4, pp. 1211-1218
Söder, O., Hellström, P.M., The tachykinins neurokinin A and physalaemin stimulate murine thymocyte proliferation (1989) Int Arch Allergy Appl Immunol, 90, pp. 91-96
Geppetti, P., Theodorsson-Norheim, E., Ballerini, G., Alessandri, M., Maggi, C.A., Santicioli, P., Amenta, F., Fanciullacci, M., Capsaicin-sensitive tachykinin-like immu-noreactivity in the thymus of rats and guinea pigs (1988) J Neuroimmunol, 19, pp. 3-9
Shigematsu, K., Saavedra, J.M., Kurihara, M., Specific substance P binding sites in rat thymus and spleen: In vitro autoradiographic study (1986) Regul Pept, 16, pp. 147-156
Vollmar, A.M., Schulz, R., Atrial natriuretic peptide is synthesized in the human thymus (1990) Endocrinology, 126, pp. 2227-2281
Vollmar, A.M., Wolf, R., Schulz, R., Co-expression of the natriuretic peptides (ANP, BNP, CNP) and their receptors in normal and acutely involuted rat thymus (1995) J Neuroimmunol, 57, pp. 117-127
Vollmar, A.M., Influence of atrial natriuretic peptide on thymocyte development in fetal thymic organ culture (1997) J Neuroimmunol, 78, pp. 90-96
Batanero, E., De Leeuw, F.E., Jansen, G.H., Van Wicken, D.F., Huber, J., Schuurman, H.J., The neural and neuroendocrine component of the human thymus (1992) Brain Behav Immun, 6, pp. 249-264
Martin-Fontecha, A., Broekhuizen, R., De Heer, C., Zapata, A., Schuurman, H.J., The neuroendocrine component of the rat thymus: Studies on cultured thymic fragments before and after transplantation in congenially athymic and euthymic rats (1993) Brain Behav Immun, 7, pp. 1-15
Savino, W., Dardenne, M., Immune-neuroendocrine interactions (1995) Immunol Today, 16, pp. 318-322
Geenen, V., Achour, I., Robert, F., Vandersmissen, E., Sodoyez, J.C., Defresne, M.P., Boniver, J., Franchimont, P., Evidence that insulin-like growth factor 2 is the dominant thymic peptide of the insulin superfamily (1993) Thymus, 21, pp. 115-127
Sodoyez, J.C., Koch, M., Lemaire, I., Sodoyez-Goffaux, F., Rapaille, A., François-Gérard, C., Sondag, D., Influence of the affinity of antibodies upon their detection by liquid phase radiobinding assay and solid phase enzyme-linked immunosorbent assay: Demonstration using monoclonal antibodies raised against rDNA human proinsulin (1991) Diabetologia, 34, pp. 463-468
Arkins, S., Rebeiz, N., Biragyn, A., Reese, D.L., Kelley, K.W., Murine macrophages express abundant insulin-like growth factor-I Ea and Eb transcripts (1993) Endocrinology, 133, pp. 2334-2343
Arkins, S., Rebeiz, N., Brunke-Reese, D.L., Biragyn, A., Kelley, K.W., Interferon-gamma inhibits macrophage insulin-like growth factor-I synthesis at the transcriptional level (1995) Mol Endocrinol, 9, pp. 350-360
Arkins, S., Rebeiz, N., Brunke-Reese, D.L., Minshall, C., Kelley, K.W., The colony-stimulating factors induce expression of insulin-like growth factor-I messenger ribonucleic acid during hematopoiesis (1995) Endocrinology, 136, pp. 1153-1160
Kecha, O., Achour, I., Hodzic, D., Goxe, B., Winkler, R., Geenen, V., IGF-II expression in the human thymus (1996) Proc 10th Int Congr Endocrinol, , abstr P1-659
Kecha, O., Achour, I., Martens, H., Winkler, R., Lefèbvre, P.J., Geenen, V., Characterization of the insulin-like growth factor (IGF) axis in the human thymus (1997) Proc 79th Annu Meeting Endoer Soc, , abstr P3-263
Van Buul-Offers, S.C., De Haan, K., Reijnen-Gresnigt, M.G., Meinsma, D., Jansen, M., Oei, S.L., Bonte, E.J., Van Den Brande, J.L., Over-expression of human insulin-like growth factor II in transgenic mice causes increased growth of the thymus (1995) J Endocrinol, 144, pp. 491-502
Pansky, B., House, E.L., Cole, L.A., An insulin-like thymic factor. A preliminary report (1965) Diabetes, 14, pp. 325-332
Zapf, J., Hauri, C., Waldvogel, M., Froesch, E.R., Acute metabolic effects and half-lives of intravenously administered insulin-like growth factors I and II in normal and hypophysectomized rats (1986) J Clin Invest, 77, pp. 1768-1775
Jolicœur, C., Hanahan, D., Smith, K.M., T-cell tolerance toward a transgenic β-cell antigen and transcription of endogenous pancreatic genes in the thymus (1994) Proc Natl Acad Sci USA, 91, pp. 6707-6711
Vafiadis, P., Bennett, S.T., Todd, J.A., Nadeau, J., Grabs, R., Goodyear, C.G., Wickramasinghe, S., Polychronakos, C., Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2locus (1997) Nat Genet, 15, pp. 289-292
Pugliese, A.A., Zeller, M., Fernandez Jr., A., Zalcberg, L.J., Bartlett, R.J., Ricordi, C., Pietropaolo, M., Patel, D.D., The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at INS VNTR-IDDM2 susceptibility locus for type 1 diabetes (1997) Nature Genet, 15, pp. 293-297
Verland, S., Gammeltoft, S., Functional receptors for insulin-like growth factors I and II in rat thymocytes and mouse thymoma cells (1989) Mol Cell Endocrinol, 67, pp. 207-216
Kozak, R.W., Hassell, J.F., Greenstein, L.A., Rechler, M.M., Waldmann, T.A., Nissley, S.P., Type 1 and 2 insulin-like growth factor receptors on human phytohemagglutinin-activated lymphocytes (1987) Cell Immunol, 109, pp. 318-331
Johnson, E.W., Jones, L.A., Kozak, R.W., Expression and function of insulin-like growth factor receptors on anti-CD3-activated human T lymphocytes (1992) J Immunol, 148, pp. 63-71
Kooijman, R., Scholtens, L.E., Rijkers, G.T., Zegers, B.J.M., Differential expression of type 1 insulin-like growth factor receptors in different stages of human T cells (1995) Eur J Immunol, 25, pp. 931-935
Kooijman, R., Van Buul-Offers, S.C., Scholtens, L.E., Schuurman, H.J., Van Den Brande, J.L., Zegers, B.J.M., T cell development in insulin-like growth factor-II transgenic mice (1995) J Immunol, 154, pp. 5736-5745
Goxe, B., Martens, H., Vandersmissen, E., Achour, I., Kecha, O., Geenen, V., Interactions entre les cellules T et la famille insulinique: Étude du récepteur de I'IGF-II (1995) Ann Endocrinol, 56, p. 399
Martens, H., Goxe, B., Geenen, V., The thymic repertoire of neuroendocrine-related self-antigens: Physiological implications in T-cell life and death (1996) Immunol Today, 17, pp. 312-317
Gammon, G., Sercarz, E., How some T cells escape tolerance induction (1989) Nature, 342, pp. 183-185
Adorini, L., Appella, E., Doria, G., Nagy, Z.A., Mechanisms influencing the immunodominance of T cell determinants (1988) J Exp Med, 168, pp. 2091-2104
Cabaniols, J.P., Cibotti, R., Kourilsky, P., Kosmatopoulos, K., Kanellopoulos, J., Dose-dependent T cell tolerance to an immunodominant self peptide (1994) Eur J Immunol, 24, pp. 1743-1749
Carraway, R.E., Ruane, S.E., Kim, H.R., Distribution and immunochemical character of neurotensin-like material in representative vertebrates and invertebrates: Apparent conservation of the COOH-terminal region during evolution (1982) Peptides, 3, pp. 115-123
Clemmons, D.R., Busby, W.H., Aral, T., Nam, T.J., Clarke, J.B., Jones, J.I., Ankrapp, D.K., Role of insulin-like grow factor binding proteins in the control of IGF actions (1995) Prog Growth Factor Res, 6, pp. 357-366
Kelley, K.M., Oh, Y., Gargosky, S.E., Gucev, Z., Matsumoto, T., Hwa, V., Ng, L., Rosenfeld, R.G., Insulin-like growth factor-binding proteins and their regulatory dynamics (1996) Int J Biochem Cell Biol, 6, pp. 619-637
Burnet, F.M., Mackay, I.R., Lymphoepithelial structures and autoimmune disease (1962) Lancet, 2, pp. 1030-1033
Like, A.A., Kislaukis, E., Williams, R.M., Rossini, A.A., Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB:W rat (1982) Science, 216, pp. 644-646
Newsom-Davis, J., Myasthenia gravis (1987) Med Int, 48, pp. 1988-1991
Georgiou, H.M., Bellgrau, D., Thymus transplantation and disease prevention in the diabetes-prone Bio-Breeding rat (1989) J Immunol, 142, pp. 3400-3405
Georgiou, H.M., Mandel, T.E., Induction of insulitis in athymic (nude) mice. The effect of NOD thymus and pancreas transplantation (1995) Diabetes, 44, pp. 49-59
Hosaka, N., Nose, M., Kyogoku, M., Nagata, N., Miyashima, S., Good, R.A., Ikehara, S., Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+ mice (1996) Proc Natl Acad Sci USA, 93, pp. 8558-8562
Whalen, B.J., Rossini, A.A., Mordes, J.P., Greiner, D.L., DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity (1995) Diabetes, 44, pp. 963-967
Thomas-Vaslin, V., Damotte, D., Coltey, M., Le Douarin, N.M., Coutinho, A., Salaün, J., Abnormal T cell selection on NOD thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice (1997) Proc Natl Acad Sci USA, 94, pp. 4598-4603
Savino, W., Carnaud, C., Luan, J.J., Bach, J.F., Dardenne, M., Characterization of the extracellular matrix-containing giant perivascular spaces in the NOD mouse thymus (1993) Diabetes, 42, pp. 134-140
Doukas, J., Mordes, J.P., Swymer, C., Niedzwiecki, D., Mason, R., Rozing, J., Rossini, A.A., Greiner, D.L., Thymic epithelial defects and predisposition to autoimmune diabetes in BB rats (1994) Am J Pathol, 145, pp. 1517-1525
Geenen, V., Achour, I., Kecha, O., Greiner, D.L., Rossini, A.A., Lefèbvre, P.J., Thymic insulin-like growth factors in man and in an animal model of autoimmune IDDM (1996) Diabetologia, 39 (1 SUPPL.), pp. A15
Atkinson, M.A., Maclaren, N.K., The pathogenesis of insulin-dependent diabetes mellitus (1994) N Engl J Med, 331, pp. 1428-1436
Conrad, B., Weidmann, E., Trucco, G., Rudert, W.A., Behboo, R., Ricordi, C., Rodriquez-Rilo, H., Trucco, M., Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology (1994) Nature, 371, pp. 351-355
Scherbaum, W.A., Bottazzo, G.F., Autoantibodies to vasopressin cells in idiopathic diabetes insipidus: Evidence for an autoimmune variant (1983) Lancet, 1, pp. 897-901
Imura, H., Nakao, K., Shimatsu, A., Ogawa, Y., Sando, T., Fujisawa, I., Yamabe, H., Lymphocytic infundibuloneurohypophysitis as a cause of central diabetes insipidus (1993) N Engl J Med, 329, pp. 683-689
Cau, P., Rougon-Capuzzi, G., Autoimmune alterations in the neurohypophysis of rabbits immunized against vasopressin (1979) Brain Res, 177, pp. 265-271
Simone, E.A., Yu, L., Wegmann, D.R., Eisenbarth, G.S., T cell receptor gene polymorphisms associated with anti-insulin, autoimmune T cells in diabetes-prone NOD mice (1997) J Autoimmun, 10, pp. 317-321
Daniel, D., Gill, R.G., Schloot, N., Wegmann, D.R., Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice (1995) Eur J Immunol, 25, pp. 1056-1062
Zhang, Z.J., Davidson, L., Eisenbarth, G.S., Weiner, H.L., Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin (1991) Proc Natl Acad Sci USA, 88, pp. 10252-10256
Daniel, D., Wegmann, D.R., Protection of non-obese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23) (1996) Proc Natl Acad Sci USA, 93, pp. 956-960
Blanas, E., Carbone, F.R., Allison, J., Miller, J.F.A.P., Heath, W.R., Induction of auto-immune diabetes by oral administration of autoantigen (1996) Science, 274, pp. 1707-1709
Toes, R.M., Offringa, R., Blom, R.J.J., Melief, C.J.M., Kast, W.M., Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction (1996) Proc Natl Acad Sci USA, 93, pp. 7855-7860
Kramer, S., Reynolds Jr., F.H., Castillo, M., Valenzuela, D.M., Thorikay, M., Sorvillo, J.M., Immunological identification and distribution of parathyroid hormone-like protein polypeptide in normal and malignant tissues (1991) Endocrinology, 128, pp. 1927-1937
Bulloch, K., McEwen, B.S., Diwa, A., Baird, S., Relationship between dehydro-epiandrosterone and calcitonin gene-related peptide in the mouse thymus (1995) Am J Physiol, 268, pp. E168-E173
