Article (Scientific journals)
Effect of ultrasound on bone fracture healing: A computational bioregulatory model
Vavva, M. G.; Grivas, K. N.; Carlier, Alain et al.
2018In Computers in Biology and Medicine, 100, p. 74-85
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Keywords :
Angiogenesis; Bone healing; Computational model; Ultrasound; Vascular endothelial growth factor; Blood vessels; Boundary conditions; Cell engineering; Endothelial cells; Ultrasonics; Acoustic pressures; Different boundary condition; Mechanical signals; Spatiotemporal evolution; Bone
Abstract :
[en] Bone healing is a complex biological procedure in which several cellular actions, directed by biochemical and mechanical signals, take place. Experimental studies have shown that ultrasound accelerates bone ossification and has a multiple influence on angiogenesis. In this study a mathematical model predicting bone healing under the presence of ultrasound is demonstrated. The primary objective is to account for the ultrasound effect on angiogenesis and more specifically on the transport of the Vascular Endothelial Growth Factor (VEGF). Partial differential equations describing the spatiotemporal evolution of cells, growth factors, tissues and ultrasound acoustic pressure and velocity equations determining the development of the blood vessel network constitute the present model. The effect of the ultrasound characteristics on angiogenesis and bone healing is investigated by applying different boundary conditions of acoustic pressure at the periosteal region of the bone model, which correspond to different intensity values. The results made clear that ultrasound enhances angiogenesis mechanisms during bone healing. The proposed model could be regarded as a step towards the monitoring of the effect of ultrasound on bone regeneration. © 2018
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Vavva, M. G.;  Dept. of Mechanical Engineering and Aeronautics, University of Patras, Patras, GR 26500, Greece
Grivas, K. N.;  Dept. of Mechanical Engineering and Aeronautics, University of Patras, Patras, GR 26500, Greece
Carlier, Alain ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Polyzos, D.;  Dept. of Mechanical Engineering and Aeronautics, University of Patras, Patras, GR 26500, Greece
Geris, Liesbet  ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique
Van Oosterwyck, H.;  Dept. of Mechanical Engineering, KU Leuven, Celestijnenlaan 300C – PB 2419, Leuven, B-3001, Belgium, MERLN Institute for Technology-inspired Regenerative Medicine, Maastricht University, Universiteitssingel 40, Maastricht, ER 6229, Netherlands
Fotiadis, D. I.;  Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, GR 45110, Greece, Foundation for Research and Technology–Hellas, Institute of Molecular Biology and Biotechnology, Department of Biomedical Research, Ioannina, GR 45110, Greece
Language :
English
Title :
Effect of ultrasound on bone fracture healing: A computational bioregulatory model
Publication date :
2018
Journal title :
Computers in Biology and Medicine
ISSN :
0010-4825
eISSN :
1879-0534
Publisher :
Elsevier Ltd
Volume :
100
Pages :
74-85
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Action “Supporting Postdoctoral Researchers” of the Operational Program “Education and Lifelong Learning” (Action’s Beneficiary: General Secretariat for Research and Technology); Greek State (PE8-3347)
Funders :
FSE - Fonds Social Européen [BE]
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since 01 August 2019

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