[en] African trypanosomiasis is the collective name for a wide variety of trypanosome infections that affect humans and livestock. In recent years, experimental mice infection models have provided new insights into both human and animal trypanosomiasis. Mouse models seem to be a valuable and versatile tool in trypanosomiasis-associated pathology and immunology research and highlight the variety shown by African trypanosomiases. Indeed, inbred mouse strains have enabled the study of genetic determinants of susceptibility and of the roles of anti-parasite antibodies, inflammatory mediators and anti-inflammatory mediators for each trypanosome species. Remarkable advances relating to the encephalitic stage of sleeping sickness have also been achieved thanks to murine models. The different contributions of murine models to the African trypanosomiases knowledge are presented here. Future search directions are finally proposed, with respect to mouse model opportunities and limitations.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Antoine-Moussiaux, Nicolas ; Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies
Magez, Stefan
Desmecht, Daniel ; Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies
Language :
English
Title :
Contributions of experimental mouse models to the understanding of African trypanosomiasis.
McCulloch R. Antigenic variation in African trypanosomes: monitoring progress. Trends Parasitol. 20 (2004) 117-121
Jennings F.W., et al. The susceptibility of strains of mice to infection with Trypanosoma congolense. Res. Vet. Sci. 25 (1978) 399-400
Morrison W.I., and Murray M. Trypanosoma congolense: inheritance of susceptibility to infection in inbred strains of mice. Exp. Parasitol. 48 (1979) 364-374
Greenblatt H.C., et al. Trypanosoma rhodesiense: analysis of the genetic control of resistance among mice. Infect. Immun. 44 (1984) 107-111
Greenblatt H.C., and Rosenstreich D. Trypanosoma rhodesiense infection in mice: sex dependence of resistance. Infect. Immun. 43 (1984) 337-340
Levine R.F., and Mansfield J.M. Genetics of resistance to African trypanosomes: role of the H-2 locus in determining resistance to infection with Trypanosoma rhodesiense. Infect. Immun. 34 (1981) 513-518
Magez S., et al. P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis. J. Infect. Dis. 189 (2004) 527-539
De Menezes V.T., et al. Trypanosoma evansi in inbred and Swiss-Webster mice: distinct aspects of pathogenesis. Parasitol. Res. 94 (2004) 193-200
Inoue N., et al. Interleukin 4 is a crucial cytokine in controlling Trypanosoma brucei gambiense infection in mice. Vet. Parasitol. 86 (1999) 173-184
Kemp S.J., et al. Genetic control of resistance to trypanosomiasis. Vet. Immunol. Immunopathol. 54 (1996) 239-243
Kemp S.J., et al. Localization of genes controlling resistance to trypanosomiasis in mice. Nat. Genet. 16 (1997) 194-196
Iraqi F., et al. Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Mamm. Genome 11 (2000) 645-648
Nakamura Y., et al. Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection. Parasitol. Res. 90 (2003) 171-174
Iraqi F., et al. Susceptibility of tumour necrosis factor-α genetically deficient mice to Trypanosoma congolense infection. Parasite Immunol. 23 (2001) 445-451
Magez S., et al. Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. J. Infect. Dis. 196 (2007) 954-962
Koudande O.D., et al. Marker-assisted introgression of trypanotolerance QTL in mice. Mamm. Genome 16 (2005) 112-119
Tabel H., et al. Susceptibility and resistance to Trypanosoma congolense infections. Microbes Infect. 2 (2000) 1619-1629
Morrison W.I., et al. Genetic control of susceptibility to T. congolense infection in inbred strains of mice. Adv. Exp. Med. Biol. 114 (1979) 709-714
Pinder M. Trypanosoma congolense: genetic control of resistance to infection in mice. Exp. Parasitol. 57 (1984) 185-194
De Gee A.L., et al. Genetics of resistance to the African trypanosomes. VI. Heredity of resistance and variable surface glycoprotein-specific immune responses. J. Immunol. 140 (1988) 283-288
De Gee A.L., and Mansfield J. Genetics of resistance to the African trypanosomes. IV. Resistance of radiation chimaeras to Trypanosoma rhodesiense infection. Cell. Immunol. 87 (1984) 85-91
Levine R.F., and Mansfield J. Genetics of resistance to the African trypanosomes. III. Variant-specific antibody responses of H-2-compatible resistant and susceptible mice. J. Immunol. 133 (1984) 1564-1569
Shi M., et al. Experimental African trypanosomiasis: IFN-γ mediates early mortality. Eur. J. Immunol. 33 (2003) 108-118
Uzonna J.E., et al. Experimental murine Trypanosoma congolense infections. I. Immunoregulation in experimental murine Trypanosoma congolense infection: anti-IL-10 antibodies reverse trypanosome-mediated suppression of lymphocyte proliferation in vitro and moderately prolong the lifespan of genetically susceptible BALB/c mice. Parasite Immunol. 20 (1998) 293-302
Uzonna J.E., et al. Experimental murine Trypanosoma congolense infections. I. Administration of anti-IFN-gamma antibodies alters trypanosome-susceptible mice to a resistant-like phenotype. J. Immunol. 161 (1998) 5507-5515
Shi M., et al. Experimental African trypanosomiasis: a subset of pathogenic, IFN-γ-producing, MHC class II-restricted CD4+ T cells mediates early mortality in highly susceptible mice. J. Immunol. 176 (2006) 1724-1732
Naessens J., et al. Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense. Vet. Parasitol. 111 (2003) 125-142
Magez S., et al. Interferon-γ and nitric oxide in combination with antibodies are key protective host immune factors during Trypanosoma congolense Tc13 infections. J. Infect. Dis. 193 (2006) 1575-1583
Baral T.N., et al. Control of Trypanosoma evansi infection is IgM mediated and does not require a type I inflammatory response. J. Infect. Dis. 195 (2007) 1513-1520
Shi M., et al. Trypanosoma congolense infections: antibody-mediated phogocytosis by Kupffer cells. J. Leukoc. Biol. 76 (2004) 399-405
Macaskill J.A., et al. Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. Immunology 40 (1980) 629-635
Hotez P.J., et al. Lipoprotein lipase suppression in 3T3-L1 cells by a haematoprotozoan-induced mediator from peritoneal exudate cells. Parasite Immunol. 6 (1984) 203-209
Beutler B., et al. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 316 (1985) 552-554
Naessens J., et al. TNF-α mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection. Clin. Exp. Immunol. 139 (2005) 405-410
Kaushik R.S., et al. Innate resistance to Trypanosoma congolense infections: differential production of nitric oxide by macrophages from susceptible BALB/c and resistant C57Bl/6 mice. Exp. Parasitol. 92 (1999) 131-143
Magez S., et al. The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors. J. Immunol. 160 (1998) 1949-1956
Drennan M.B., et al. The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J. Immunol. 175 (2005) 2501-2509
Lucas R., et al. Mapping the lectin-like activity of tumor necrosis factor. Science 263 (1994) 814-817
Magez S., et al. Specific uptake of tumor necrosis factor-α is involved in growth control of Trypanosoma brucei. J. Cell Biol. 137 (1997) 715-727
Magez S., et al. Murine tumour necrosis factor plays a protective role during the initial phase of the experimental infection with Trypanosoma brucei brucei. Parasite Immunol. 15 (1993) 635-641
Magez S., et al. Tumor necrosis factor α is a key mediator in the regulation of experimental Trypanosoma brucei infections. Infect. Immun. 67 (1999) 3128-3132
Magez S., et al. Control of experimental Trypanosoma brucei infections occurs independently of lymphotoxin-α induction. Infect. Immun. 70 (2002) 1342-1351
Kitani H., et al. Recombinant tumor necrosis α does not inhibit the growth of African trypanosomes in axenic cultures. Infect. Immun. 70 (2002) 2210-2214
Chiejina S., et al. Concurrent infections with Trypanosoma brucei and Nippostrongylus brasiliensis in mice deficient in inducible nitric oxide. Parasitol. Int. 52 (2003) 107-115
Hertz C.J., and Mansfield J. IFN-γ-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell. Immunol. 192 (1999) 24-32
Millar A.E., et al. T-cell responses during Trypanosoma brucei infections in mice deficient in inducible nitric oxide synthase. Infect. Immun. 67 (1999) 3334-3338
Sternberg J., et al. Inhibition of nitric oxide synthesis leads to reduced parasitaemia in murine Trypanosoma brucei infection. Infect. Immun. 62 (1994) 2135-2137
Mabbott N., and Sternberg J. Bone marrow nitric oxide production and development of anaemia in Trypanosoma brucei-infected mice. Infect. Immun. 63 (1995) 1563-1566
Noel W., et al. Infection stage-dependent modulation of macrophage activation in Trypanosoma congolense-resistant and -susceptible mice. Infect. Immun. 70 (2002) 6180-6187
Namangala B., et al. Relative contribution of interferon-γ and interleukin-10 to resistance to murine African trypanosomosis. J. Infect. Dis. 183 (2001) 1794-1800
Namangala B., et al. Alternative versus classical macrophage activation during experimental African trypanosomosis. Int. J. Parasitol. 31 (2001) 575-587
Guilliams M., et al. African trypanosomiasis: naturally accruing regulatory T-cells favor trypanotolerance by limiting pathology associated with sustained type 1 inflammation. J. Immunol. 179 (2007) 2748-2757
Kennedy P.G. Diagnostic and neuropathogenesis issues in human African trypanosomiasis. Int. J. Parasitol. 36 (2006) 505-512
Kennedy P.G. Animal models of human African trypanosomiasis: very useful or too far removed?. Trans. R. Soc. Trop. Med. Hyg. 101 (2007) 1061-1062
Masocha W., et al. Migration of African trypanosomes across the blood-brain barrier. Physiol. Behav. 92 (2007) 110-114
Sternberg J.M., et al. Meningoencephalitic African trypanosomiasis: brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology. J. Neuroimmunol. 167 (2005) 81-89
Hunter C.A., et al. Astrocyte activation correlates with cytokine production in central nervous system of Trypanosoma brucei brucei-infected mice. Lab. Invest. 67 (1992) 635-642
Eckersall P.D., et al. Cytokines and the acute phase response in post-treatment reactive encephalopathy of Trypanosoma brucei brucei infected mice. Parasitol. Int. 50 (2001) 15-26
Hunter C.A., et al. Correlation of autoantibody titres with central nervous system pathology in experimental African trypanosomiasis. J. Neuroimmunol. 41 (1992) 143-148
Kennedy P.G., et al. A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 4167-4170
Kennedy P.G., et al. Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. Brain 126 (2003) 1683-1690
Masocha W., et al. Cerebral vessel laminins and IFN-γ define Trypanosoma brucei brucei penetration of the blood-brain barrier. J. Clin. Invest. 114 (2004) 689-694
Masocha W., et al. Minocycline impedes African trypanosome invasion of the brain in a murine model. Antimicrob. Agents Chemother. 50 (2006) 1798-1804
Joshi P.P., et al. Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report. Am. J. Trop. Med. Hyg. 73 (2005) 491-495
Vanhollebeke B., et al. Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-1. N. Engl. J. Med. 355 (2006) 2752-2756
Taylor K., et al. Nitric oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression. Infect. Immun. 64 (1996) 4115-4122
Williams D.J., et al. The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance. Parasite Immunol. 18 (1996) 209-218
Sternberg J.M. Human African trypanosomiasis: clinical presentation and immune response. Parasite Immunol. 26 (2004) 469-476
Courtin D., et al. Interest of tumor necrosis factor-α -308 G/A and interleukin-10-2 C/A polymorphisms in human African trypanosomiasis. Infect. Genet. Evol. 6 (2006) 123-129
