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The effects of cognitive load on cognitive fatigue in Multiple Sclerosis - Preliminary results
Guillemin, Camille; Requier, Florence; Delvenne, Julie et al.
2021BAPS 2021 Annual Meeting
 

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Keywords :
Multiple Sclerosis; Cognitive Fatigue; Cognitive Load
Abstract :
[en] Background. Cognitive fatigue is one of the most frequent and debilitating symptom of Multiple Sclerosis (MS). While it is well established that MS patients show a decrement of performances during/following a long cognitive task, only few studies investigated the effects of cognitive load on MS-related fatigue. Objective. To explore the effects of cognitive load on performance decrement and pupil variations in MS. Methods. Thirteen patients with early MS (disease duration <5) and 12 matched healthy subjects performed a dual-task in cognitive load conditions (low and high). High cognitive load was adjusted to individual resources by determining the fastest presentation rate leading to at least 85% accuracy; the low cognitive load condition is 50% slower. Additionally, pupil size variations were obtained during the task for 6 patients and 7 controls. Repeated measures ANOVA were performed to determine the group, time and cognitive load effects on averaged performances and pupil size. Supplementary analysis were conducted on performances using Bayesian statistics. Results. ANOVA on performances revealed an effect of condition (F(1,20)=37.79, p<.0001) and time (F(3,20)=13.32, p<.0001) but no effect of group nor interaction effects. Bayesian statistical analysis revealed an absence of difference in performances’ evolution between groups (BF01=5.71). ANOVA for pupil size revealed a tendency to significance for the group*condition interaction (p=0.077). Discussion. MS patients did not demonstrate larger fatigue effects on performances than control when the task is adapted to individual resources. The lack of pupillary response to cognitive load seems to reflect cognitive fatigue in patients despite behavioral compensation.
Disciplines :
Theoretical & cognitive psychology
Neurosciences & behavior
Author, co-author :
Guillemin, Camille ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
Requier, Florence  ;  Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Delvenne, Julie;  Université de Liège - ULiège
Hammad, Grégory  ;  Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
DELRUE, Gaël ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Médecine de l'appareil locomoteur (RNCL - Neuropsychologie)
LOMMERS, Emilie  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie
Maquet, Pierre  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Collette, Fabienne  ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
Language :
English
Title :
The effects of cognitive load on cognitive fatigue in Multiple Sclerosis - Preliminary results
Publication date :
28 May 2021
Event name :
BAPS 2021 Annual Meeting
Event organizer :
​Belgian Association of Psychological Sciences (BAPS)
Event date :
27th et 28th May 2021
Available on ORBi :
since 12 July 2021

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