Effect of Coxsackievirus B4 Infection on the Thymus: Elucidating Its Role in the Pathogenesis of Type 1 Diabetes

[en] The thymus gland is a primary lymphoid organ for T-cell development. Various viral infections can result in disturbance of thymic functions. Medullary thymic epithelial cells (mTECs) are important for the negative selection of self-reactive T-cells to ensure central tolerance. Insulin-like growth factor 2 (IGF2) is the dominant self-peptide of the insulin family expressed in mTECs and plays a crucial role in the intra-thymic programing of central tolerance to insulin-secreting islet β-cells. Coxsackievirus B4 (CVB4) can infect and persist in the thymus of humans and mice, thus hampering the T-cell maturation and differentiation process. The modulation of IGF2 expression and protein synthesis during a CVB4 infection has been observed in vitro and in vivo in mouse models. The effect of CVB4 infections on human and mouse fetal thymus has been studied in vitro. Moreover, following the inoculation of CVB4 in pregnant mice, the thymic function in the fetus and offspring was disturbed. A defect in the intra-thymic expression of self-peptides by mTECs may be triggered by CVB4. The effects of viral infections, especially CVB4 infection, on thymic cells and functions and their possible role in the pathogenesis of type 1 diabetes (T1D) are presented.

Research center :

GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège

Disciplines :

Immunology & infectious disease
Endocrinology, metabolism & nutrition

Author, co-author :

Alhazmi, abdelaziz; Univdersité de Lille > Laboratoire de Virologie ULR3610

Nekoua, Magloire-Pandou; Université de Lille > Laboratoire de Virologie ULR3610

Michaux, Hélène; Université de Liège - ULiège > GIGA-I3 Neuroimmunoendocrinologie

Sane, Famara; CHRU Lille > Laboratoire de Virologie ULR3610

Halouani, Aymen; Université de Monastir > LR99ES27

Engelmann, Ilka; CHRU Lille > Laboratoire de Virologie ULR3610

Alidjinou, Enagon Kayla; CHRU Lille > Laboratoire de Virologie ULR3610

Martens, Henri ; Université de Liège - ULiège > GIGA I3 - Immunoendocrinology

Jaïdane, Hela; Université de Monastir > LR99ES27

Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie

Hober, Didier; Université de Lille > Laboratoire de Virologie ULR3610

Language :

English

Title :

Effect of Coxsackievirus B4 Infection on the Thymus: Elucidating Its Role in the Pathogenesis of Type 1 Diabetes

Publication date :

21 May 2021

Journal title :

Microorganisms

eISSN :

2076-2607

Publisher :

Molecular Diversity Preservation International (MDPI), Basel, Switzerland

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 July 2021

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