Ameliorative or corrective effects of Fig “Ficus carica” extract on nickel-induced hepatotoxicity in Wistar rats

Nemiche, Souhila; Hait Hamadouche, Nadia; Nemmiche, Said; Fauconnier, Marie-Laure; Tou, Abdenacer

doi:10.1007/s43188-021-00118-w

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Ameliorative or corrective effects of Fig “Ficus carica” extract on nickel-induced hepatotoxicity in Wistar rats

Nemiche, Souhila; Hait Hamadouche, Nadia; Nemmiche, Said et al.

2022 • In Toxicological Research, 38, p. 311-321

Peer reviewed

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https://hdl.handle.net/2268/267787

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10.1007/s43188-021-00118-w

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Keywords :

Ficus carica; Nickel; oxidative stress; liver; Wistsar rats

Abstract :

[en] Many heavy metals and metalloids (e.g., Pb, Cd, and Ni) can contaminate the environment and cause severe health problems. Through this study, investigated the possible corrective effects of Ficus carica extract (FCE) against nickel (Ni) induced stress response and damage on the liver of rats. Male Wistar rats were divided into four groups (8 rats per group) and co-treated with FCE (350 mg/kg) and exposed to Nickel chloride (10 mg/kg) for 4 weeks. The volatile compounds of FCE were characterized by solid phase micro-extraction (SPME) coupled with GC–MS, and the biochemical parameters of stress were determined. The SPME–GC/MS analysis of FCE indicated the presence of thirty (30) phyto-bioactive compounds including alcohols, aldehydes, organic acids, ketones, furans, terpenes, ester and others. The best capacity for scavenging DPPH free radicals and metal chelating were found with the IC50 values of 0.49 and 2.91 mg/mL, respectively. Ni induced damage to various macromolecules. Malondialdehyde, protein carbonyls, alanine aminotransferase and gamma glutamyl transferarse levels were significantly increased in Ni exposed group compared to control group and co-treatment with FCE reduced the levels of these parameters. In conclusion, current findings showed that Ni-induced oxidative damage and the administration of FCE can improve correct and restore the alteration in the rat liver.

Disciplines :

Gastroenterology & hepatology
Chemistry

Author, co-author :

Nemiche, Souhila

Hait Hamadouche, Nadia

Nemmiche, Said

Fauconnier, Marie-Laure ; Université de Liège - ULiège > Département GxABT > Chimie des agro-biosystèmes

Tou, Abdenacer

Language :

English

Title :

Ameliorative or corrective effects of Fig “Ficus carica” extract on nickel-induced hepatotoxicity in Wistar rats

Publication date :

18 January 2022

Journal title :

Toxicological Research

ISSN :

1976-8257

Publisher :

Koreal Association of Medical Journal Editors, South Korea

Volume :

Pages :

311-321

Peer reviewed :

Peer reviewed

Additional URL :

https://link.springer.com/content/pdf/10.1007/s43188-021-00118-w.pdf?pdf=button

Available on ORBi :

since 03 February 2022

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