Article (Scientific journals)
Oral taurine supplementation modulates ethanol-conditioned stimulus preference
Quertemont, Etienne; Goffaux, Valérie; Vlaminck, Anne-Michèle et al.
1998In Alcohol, 16 (3), p. 201-206
Peer reviewed
 

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Keywords :
Ethanol; Taurine; Conditioned place preference
Abstract :
[en] The present study investigated the possible modulatory action of oral taurine supplementation on the rewarding and aversive properties of low and high ethanol doses in male Wistar rats. A vinegar odor stimulus was daily paired with either ethanol (0.3 or 2.0 g/kg) or saline. In addition, half of the rats were supplemented orally with taurine (0.5 g/kg/day). After eight conditioning sessions, all rats were tested for their vinegar stimulus preference or aversion. In nontaurine-treated rats, 2.0 g/kg ethanol conditioning induced a significant aversion for the vinegar stimulus, while there was no preference after 0.3 g/kg ethanol conditioning. However, in taurine-supplemented rats, the 2.0 g/kg ethanol-induced aversion for the stimulus was decreased significantly, while the rats administered the lower ethanol doses, 0.3 g/kg, in combination with taurine supplementation, demonstrated a significant stimulus preference. Such results suggest that taurine modulates some of the aversive or rewarding effects of ethanol.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Neurosciences & behavior
Psychiatry
Pharmacy, pharmacology & toxicology
Author, co-author :
Quertemont, Etienne  ;  Université de Liège - ULiège > Département des sciences cognitives > Psychologie quantitative
Goffaux, Valérie;  Université Catholique de Louvain - UCL > Biologie > Biologie du Comportement
Vlaminck, Anne-Michèle;  Université Catholique de Louvain - UCL > Biologie > Biologie du Comportement
Wolf, Charlotte;  Université Catholique de Louvain - UCL > Biologie > Biologie du Comportement
De Witte, Philippe;  Université Catholique de Louvain - UCL > Biologie > Biologie du Comportement
Language :
English
Title :
Oral taurine supplementation modulates ethanol-conditioned stimulus preference
Publication date :
1998
Journal title :
Alcohol
ISSN :
0741-8329
eISSN :
1873-6823
Publisher :
Elsevier
Volume :
16
Issue :
3
Pages :
201-206
Peer reviewed :
Peer reviewed
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fonds de Développement Scientifique de l'UCL
IREB - Institut de Recherches Scientifiques sur les Boissons [FR]
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