[en] A simple, rapid and reliable reversed-phase high-performance liquid chromatographic method for the determination of tagitinin C, an anti-plasmodial sesquiterpene lactone isolated from the aerial parts of Tithonia diversifolia, has been developed. The assay has been used to quantify tagitinin C in various extracts of the aerial parts of T. diversifolia.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Goffin, Eric ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
da Cunha, Antonio Proenca; University of Coimbra - UC > Faculty of Pharmacy > Laboratory of Pharmacognosy
Ziemons, Eric ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Tits, Monique ; Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Angenot, Luc ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Quantification of tagitinin C in Tithonia diversifolia by reversed-phase high-performance liquid chromatography.
Publication date :
November 2003
Journal title :
Phytochemical Analysis
ISSN :
0958-0344
eISSN :
1099-1565
Publisher :
John Wiley & Sons Ltd., West Sussex, United Kingdom
Baruah NC, Sharma RP, Madhusudanan KP, Thyagarajan G. 1979. Sesquiterpene lactones of Tithonia diversifolia. Stereochemistry of the tagitinins and related compounds. J Org Chem 44: 1831-1835.
Bordoloi M, Barua NC, Ghosh AC. 1996. An artemisinic acid analogue from Tithonia diversifolia. Phytochemistry 41: 557-559.
do Céu de Madureira M, Martins AP, Gomes M, Paiva J, Proença da Cunha A, do Rosário V. 2002. Anti-malarial activity of medicinal plants used in traditional medicine in S. Tomé and Príncipe islands. J Ethnopharmacol 81: 23-29.
Goffin E, Ziemons E, De Mol P, de Céu de Madureira M, Martins AP, Proença da Cunha A, Philippe G, Tits M, Angenot L, Frederich M. 2002. In vitro anti-plasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C. Planta Med 68: 541-543.
Kuo Y-H, Chen C-H. 1998. Sesquiterpenes from the leaves of Tithonia diversifolia. J Nat Prod 61: 827-828.
Pal R, Kulshreshta DK, Rastogi RP. 1977. Chemical constituents of Tithonia tagitiflora Desf.: part IV - tagitinins C, D and F. Indian J Chem 15B: 208-211.
Pereira PS, Dias DA, Vichnewski W, Nasi AM, Herz W. 1997. Sesquiterpene lactones from Brazilian Tithonia diversifolia. Phytochemistry 45: 1445-1448.
Schuster A, Stokes S, Papastergiou F, Castro V, Poveda L, Jakupovic J. 1992. Sesquiterpene lactones from two Tithonia species. Phytochemistry 31: 3139-3141.
