Oxidative Stress in the Cochlea: An Update.

[en] This paper will focus on understanding the role and action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the molecular and biochemical pathways responsible for the regulation of the survival of hair cells and spiral ganglion neurons in the auditory portion of the inner ear. The pivotal role of ROS/RNS in ototoxicity makes them potentially valuable candidates for effective otoprotective strategies. In this review, we describe the major characteristics of ROS/RNS and the different oxidative processes observed during ototoxic cascades. At each step, we discuss their potential as therapeutic targets because an increasing number of compounds that modulate ROS/RNS processing or targets are being identified.

Disciplines :

Otolaryngology
Biochemistry, biophysics & molecular biology
Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Poirrier, Anne-Lise ; Centre Hospitalier Universitaire de Liège - CHU > O.R.L.

Pincemail, Joël ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire

Van Den Ackerveken, Priscilla

Lefèbvre, Philippe ; Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie

Malgrange, Brigitte ; Université de Liège - ULiège > GIGA - Neurosciences - Neurologie

Language :

English

Title :

Oxidative Stress in the Cochlea: An Update.

Publication date :

2010

Journal title :

Current Medicinal Chemistry

ISSN :

0929-8673

eISSN :

1875-533X

Publisher :

Bentham Science Publishers Ltd., Schiphol, Netherlands

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 August 2010

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113 (22 by ULiège)

Number of downloads

6 (4 by ULiège)

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Scopus citations^®

117

Scopus citations^®
without self-citations

117

OpenCitations

108

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