Article (Scientific journals)
Effects of Schwann Cell Transplantation in a Contusion Model of Rat Spinal Cord Injury
Martin, Didier; Robe, Pierre; Franzen, Rachelle et al.
1996In Journal of Neuroscience Research, 45 (5), p. 588-597
Peer Reviewed verified by ORBi
 

Files


Full Text
J Neurosci Res 45 (1996) 588-597 - Martin - SCI and Schwann transplant.pdf
Publisher postprint (1.77 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Animals; Axons/immunology/physiology; Female; Ganglia, Spinal/cytology/transplantation; Graft Survival; Image Processing, Computer-Assisted; Nerve Regeneration/physiology; Rats; Rats, Wistar; Schwann Cells/transplantation; Spinal Cord Injuries/pathology/therapy
Abstract :
[en] Cultured Schwann cells were transplanted at various delays into a spinal cord contusion injury performed at low thoracic level in adult female rats. The Schwann cells were purified from the dorsal root ganglia of adult syngeneic animals. the transplants were well tolerated, and the transplanted Schwann cells invaded the injured spinal cord. As quantified using video image analysis, the survival and growth of the transplanted cells were poor when the grafting procedure was performed 3-4 days after injury and very good when performed immediately or 10 days after injury, in which cases post-traumatic micro- and macrocavitation were strongly reduced. In animals grafted immediately after injury but not in animals grafted after 10 days, post-traumatic astrogliosis was much reduced. The Schwann cells transplanted area was invaded by numerous regenerating axons, the vast majority of which were, based on the neurotransmitter (CGRP and SP) profile, originating from dorsal root ganglion. No regeneration of the corticospinal tract as assessed after anterograde tracing or of descending aminergic fibers could be demonstrated.
Disciplines :
Surgery
Author, co-author :
Martin, Didier  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurochirurgie
Robe, Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine
Franzen, Rachelle  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Delree, P.
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Stevenaert, Achille ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Moonen, Gustave  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine
Language :
English
Title :
Effects of Schwann Cell Transplantation in a Contusion Model of Rat Spinal Cord Injury
Publication date :
01 September 1996
Journal title :
Journal of Neuroscience Research
ISSN :
0360-4012
eISSN :
1097-4547
Publisher :
Wiley Interscience, New York, United States - New York
Volume :
45
Issue :
5
Pages :
588-597
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 July 2010

Statistics


Number of views
73 (8 by ULiège)
Number of downloads
2 (2 by ULiège)

Scopus citations®
 
111
Scopus citations®
without self-citations
106
OpenCitations
 
85

Bibliography


Similar publications



Contact ORBi