[en] A patient with type AB thymoma and del(6)(p22p25) as the sole cytogenetic anomaly is described. This is the second report of a del(6)(p22p25) in a thymoma. The same deletion was previously found in association with a type A thymoma. Both patients presented with benign tumors. These data suggest that partial deletion of the short arm of chromosome 6 is a nonrandom change associated with benign thymomas. (C) 2003 Elsevier Inc. All rights reserved.
Disciplines :
Oncology Genetics & genetic processes
Author, co-author :
Herens, Christian ; Centre Hospitalier Universitaire de Liège - CHU > PLAN COS
Radermecker, Maurice ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Servais, Anne-Marie ; Centre Hospitalier Universitaire de Liège - CHU > Administration des patients - Inscription policliniques
Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Jardon-Jeghers, C.
Bours, Vincent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine
de Leval, Laurence ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Language :
English
Title :
Deletion (6)(p22p25) is a recurrent anomaly of thymoma: report of a second case and review of the literature
Publication date :
01 October 2003
Journal title :
Cancer Genetics and Cytogenetics
ISSN :
0165-4608
eISSN :
1873-4456
Publisher :
Elsevier Science, New York, United States - New York
Histological typing of tumors of the thymus. Rosai J., Sobin L.H. WHO international histological classification of tumors. 1999;1-65 Springer Verlag.
Müller-Hermelink H.K., Marx A. Pathological aspects of malignant and benign thymic disorders. Ann Med. 31:1999;5-14.
Kristofferson U., Heim S., Mandahl N., Akerman M., Mitelman F. Multiple clonal chromosome aberrations in two thymomas. Cancer Genet Cytogenet. 41:1989;93-98.
Kubonishi I., Takehara N., Iwata J., Sonobe H., Ohtsuki Y., Abe T., Miyoshi I. Novel t(15;19)(q15;p13): chromosome abnormality in a thymic carcinoma. Cancer Res. 51:1991;3327-3328.
Kees U.R., Mulcahy M.T., Willoughby M. Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19). Am J Pediatr Hematol Oncol. 13:1991;459-464.
Lee A.C.W., Kwong Y.-L., Hang K., Chan G., Ma L., Lau Y.-L. Disseminated mediastinal carcinoma with chromosomal translocation (15;19). A distinctive clinicopathologic syndrome. Cancer. 72:1993;2273-2276.
Dal Cin P., De Wolf-Peeters C., Aly M., Deneffe G., Van Mieghem W., Van Den Berghe H. Ring chromosome 6 as the only change in a thymoma. Genes Chromosomes Cancer. 6:1993;243-244.
Dal Cin P., De Wolf-Peeters C., Deneffe G., Fryns J.-P., Van Den Berghe H. Thymoma with a t(15;22)(p11;q11). Cancer Genet Cytogenet. 89:1996;181-183.
Sonobe H., Ohtsuki Y., Nakayama H., Asaba K., Nishiya K., Shimizu K. A thymic squamous cell carcinoma with complex chromosome abnormalities. Cancer Genet Cytogenet. 103:1998;83-85.
Sonobe H., Takeuchi T., Ohtsuki Y., Taguchi T., Shimizu K. A thymoma with clonal complex chromosome abnormalities. Cancer Genet Cytogenet. 110:1999;72-74.
Sait S.N.J., Brooks J.J., Ashraf M., Zhang P.J. A novel t(1;8)(p13;p11) in a thymic carcinoma with unusual giant cell features and renal metastasis. Cancer Genet Cytogenet. 124:2001;140-143.
Mirza I., Kazimi S.N., Ligi R., Burns J., Braza F. Cytogenetic profile of a thymoma. A case report and review of the literature. Arch Pathol Lab Med. 124:2000;1714-1716.
Goh S.G., Lau L.C., Sivaswaren C., Chuah K.L., Tan P.H., Lai D. Pseudodicentric (16;12)(q11;p11.2) in a type AB (mixed) thymoma. Cancer Genet Cytogenet. 131:2001;42-47.
Limon J., Dal Cin P., Sandberg A.A. Application of long term collagenase disaggregation for the cytogenetic analysis of human solid tumors. Cancer Genet Cytogenet. 23:1986;305-313.
Zettl A., Ströbel P., Wagner K., Katzenberger T., Ott G., Rosenwald A., Peters K., Krein A., Semik M., Müller-Hermelink H.-K., Marx A. Recurrent genetic aberrations in thymoma and thymic carcinoma. Am J Pathol. 157:2000;257-266.
Inoue M., Marx A., Zettl A., Stöbel P., Müller-Hermelink H.K., Starostik P. Chromosome 6 suffers frequent and multiple aberrations in thymoma. Am J Pathol. 161:2002;1507-1512.
