Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.

Adult; Anisotropy; Deanol/pharmacology; Dermatologic Agents/pharmacology; Dermatology/methods; Double-Blind Method; Female; Gels; Humans; Middle Aged; Pilot Projects; Skin/drug effects; Skin Physiological Phenomena/drug effects; Suction; Tensile Strength; Vehicles/pharmacology

Abstract :

[en] BACKGROUND/AIMS: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. METHODS: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. RESULTS: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness. CONCLUSION: The DMAE formulation under investigation increased skin firmness.

Disciplines :

Dermatology

Author, co-author :

Uhoda, Isabelle; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Faska, Najat

Robert, Caroline

Cauwenbergh, Geert; Barrier Therapeutics, NV, Geel, Belgium

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel.

Publication date :

2002

Journal title :

Skin Research and Technology

ISSN :

0909-752X

eISSN :

1600-0846

Publisher :

Blackwell, Oxford, United Kingdom

Volume :

Issue :

Pages :

164-7

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 March 2009

Statistics

Number of views

416 (2 by ULiège)

Number of downloads

784 (1 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

Bibliography

Jope RS, Jenden DJ. Dimethylaminoethanol (deanol) metabolism in rat brain and its effect on acetylcholine synthesis. J Pharmacol Exp Ther 1979; 211: 472-479.
Haubrich DR, Gerber HH, Pflueger AB. Deanol affects choline metabolism in peripheral tissues of mice. J Neurochem 1981; 37:476-482.
Grando SA, Horton RM, Pereira EF et al. A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes. J Invest Dermatol 1995; 105: 774-781.
Grando SA, Horton RM, Mauro TM et al. Activation of keratinocyte nicotinic cholinergic receptors stimulates calcium influx and enhances cell differantiation. J Invest Dermatol 1996; 107: 412-418.
Grando SA. Biological functions of keratinocyte cholinergic receptors. J Invest Dermatol Symp Proc 1997; 2:41-48.
Nodoye A, Buchi R, Greenberg B et al. Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis. J Invest Dermatol 1998; 111:410-416.
Buchli R, Ndoye A, Rodriguez G, Zia S, Webber RJ, Grando SA. Human skin fibroblasts express m2, 34 and 35 subtypes of muscarinic acetylcholine receptors. J Cell Biochem 1999; 74: 264-277.
Klapproth H, Reinheimer T, Metzen J et al. Non-neuronal acetylcholine, a signalling molecule synthesized by surface cells of rat and man. Naunyn-Schmiedebergs Arch Pharmacol 1997; 355: 515-523.
Piérard-Franchimont C, Cornil F, Dehavay J et al. Climacteric skin ageing of the face. A prospective longitudinal intent-to-treat trial on the effect of oral hormone replacement therapy. Maturitas 1999; 32: 87-93.
Piérard GE. The EEMCO group. EEMCO guidance to the in vivo assessment of tensile functional properties of the skin. Part 1: Relevance to the structures and ageing of the skin and subcutaneous tissues. Skin Pharmacol Appl Skin Physiol 1999; 12: 352-362.
Nizet JL, Piérard-Franchimont C, Piérard GE. Influence of the body posture and gravitatioal forces on shear wave propagation in the skin. Dermatology 2001; 202: 177-180.
Hermanns-Lê T, Jonlet F, Scheen A, Piérard GE. Age and body mass index-related changes in cutaneous shear wave velocity. Exp Gerontol 2001; 36: 363-372.
Martalo O, Henry F, Piérard GE. Seuil liminaire de la perception d'un étirement cutané. Ann Dermatol Venereol 2001; 128: 119-122.
Paquet P, Piérard-Franchimont C, Fumal I et al. Sensitive skin at menopause; dew point and electrometric properties of the stratum corneum. Maturitas 1998; 28: 221-227.
Van Cromphaut I, Fumal I, Jacquemin D et al. Skin barrier repair after burns. Electrometric evaluation using the passive sustainable hydration test. J Envir Med 1999; 1: 47-50.
Piérard GE, Piérard-Franchimont C, Marks R et al. EEMCO guidance for the in vivo assessment of skin greasiness. Skin Pharmacol Appl Skin Physiol 2000; 13: 372-389.
Potts RO, Chrisman DA, Burns EM. The dynamic mechanical properties of human skin in vivo. J Biomech 1983; 16: 365-372.
Potts RO, Buras EM Jr, Chrisman DA. Changes with age in the moisture content of human skin. J Invest Dermatol 1984; 82: 97-100.
Davis BR, Bahniuk E, Young JK et al. Age dependent changes in shear wave propagation through human skin. Exp Gerontol 1989; 24: 202-210.
Vexler A, Polyansky I, Gorodetsky R. Evaluation of skin viscoelasticity and anisotropy by measurement of speed of shear wave propagation with viscoelasticity skin analyzer. J Invest Dermatol 1999; 113: 732-739.
Langer K. Zur Anatomie und Physiologie der Haut. III-Uber die Elasticität der Cutis. Sitzeungsber Math Cl Kaiserlich Acad Wiss 1862; 45: 156.
Borges AF, Alexander JE. Relaxed skin ension lines, Z-plasties on scars, and fusiform excision of lesions. Br J Plast Surg 1962; 15: 242-254.
Borges AF. Relaxed skin tension lines (RSTL) versus other skin lines. Plast Reconstr Surg 1984; 73: 144-150.
Alexander CH, Cook TH. Accounting for the natural tension in the mechanical testing of human skin. J Invest Dermatol 1977; 69: 310-314.
Piérard GE, Lapière CHM. Microanatomy of the dermis in relation of relaxed skin tension lines and Langer's lines. Am J Dermatopathol 1987; 9: 219-224.