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Nerve growth factor, pain, itch and inflammation: lessons from congenital insensitivity to pain with anhidrosis
http://hdl.handle.net/2298/23889
http://hdl.handle.net/2298/2388998ba2ae8-c12f-44ff-b431-8cd409d5d81f
| 名前 / ファイル | ライセンス | アクション |
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Reposit-ERN-2010-Figure.pdf (148.7 kB)
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Reposit-ERN-2010.pdf (143.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-11-15 | |||||
| タイトル | ||||||
| タイトル | Nerve growth factor, pain, itch and inflammation: lessons from congenital insensitivity to pain with anhidrosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Nerve growth factor (NGF), 神経成長因子, Receptor tyrosine kinase for NGF, チロシンキナーゼ型神経成長因子受容体, TrkA protein, TrkA タンパク質, NTRK1 gene, NTRK1 遺伝子, TRKA gene, TRKA 遺伝子, Congenital insensitivity to pain with anhidrosis, 先天性無痛無汗症, Interoception, 内感覚, Polymodal receptor, ポリモーダル受容器, Sympathetic neuron, 交感神経ニューロン, Basal forebrain cholinergic neuron, 前脳基底野コリン作動性ニューロン, Emotion, 情動, Pain, 痛み, 疼痛, Homeostasis, 恒常性, Hereditary sensory and autonomic neuropathy type IV, 遺伝性感覚自律神経性ニュー ロパシー IV 型, NGF-dependent primary afferent neuron, NGF 依存性一次求心性ニューロン, itch, 痒み, inflammation, 炎症 | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Indo, Yasuhiro
× Indo, Yasuhiro |
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| 別言語の著者 |
犬童, 康弘
× 犬童, 康弘 |
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| 内容記述 | ||||||
| 内容記述 | NGF is a well-known neurotrophic factor essential for the survival and maintenance of primary afferent neurons and sympathetic neurons. NGF is also an inflammatory mediator associated with pain and itch. Congenital insensitivity to pain with anhidrosis is a genetic disorder due to loss-of-function mutations in the NTRK1 gene encoding TrkA, a receptor tyrosine kinase for NGF. Since patients with congenital insensitivity to pain with anhidrosis lack NGF-dependent unmyelinated (C-) and thinly myelinated (Aδ-) fibers, and their dermal sweat glands are without innervation, they exhibit no pain, itch, signs of neurogenic inflammation or sympathetic skin responses. Based on the pathophysiology of congenital insensitivity to pain with anhidrosis, this article indicates how NGF-dependent neurons are essential for the establishment of neural networks for interoception and homeostasis, and play crucial roles in brain-immune-endocrine interactions in pain, itch and inflammation. In addition, it refers to involvements of the NGF-TrkA system in various disease states, and potential pharmacological effects when this system is targeted. | |||||
| 書誌情報 |
Expert Review of Neurotherapeutics 巻 10, 号 11, p. 1707-1724, 発行年 2010-11 |
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| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1586/ern.10.154 | |||||
| 権利 | ||||||
| 権利情報 | 2010 Expert Reviews Ltd, | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 143523 bytes | ||||||
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| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
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| 出版者 | Expert Reviews | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.expert-reviews.com/doi/abs/10.1586/ern.10.154 | |||||
| コメント | ||||||
| Theme: Pain - Review | ||||||
