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タイトル: | Stress responses: the contribution of prostaglandin E(2) and its receptors. |
著者: | Furuyashiki, Tomoyuki Narumiya, Shuh |
著者名の別形: | 古屋敷, 智之 |
発行日: | Mar-2011 |
出版者: | Nature Publishing Group |
誌名: | Nature reviews. Endocrinology |
巻: | 7 |
号: | 3 |
開始ページ: | 163 |
終了ページ: | 175 |
抄録: | Stress is a state of physiological or psychological strain caused by adverse stimuli; responses to stress include activation of the sympathetic nervous system, glucocorticoid secretion and emotional behaviors. Prostaglandin E(2) (PGE(2)), acting through its four receptor subtypes (EP1, EP2, EP3 and EP4), is involved in these stress responses. Studies of EP-selective drugs and mice lacking specific EPs have identified the neuronal pathways regulated by PGE(2). In animals with febrile illnesses, PGE(2) acts on neurons expressing EP3 in the preoptic hypothalamus. In illness-induced activation of the hypothalamic-pituitary-adrenal axis, EP1 and EP3 regulate distinct neuronal pathways that converge at the paraventricular hypothalamus. During psychological stress, EP1 suppresses impulsive behaviors via the midbrain dopaminergic systems. PGE(2) promotes illness-induced memory impairment, yet also supports hippocampus-dependent memory formation and synaptic plasticity via EP2 in physiological conditions. In response to illness, PGE(2) is synthesized by enzymes induced in various cell types inside and outside the brain, whereas constitutively expressed enzymes in neurons and/or microglia synthesize PGE(2) in response to psychological stress. Dependent on the type of stress stimuli, PGE(2) released from different cell types activates distinct EP receptors, which mobilize multiple neuronal pathways, resulting in stress responses. |
著作権等: | © 2011 Macmillan Publishers Limited. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/156404 |
DOI(出版社版): | 10.1038/nrendo.2010.194 |
PubMed ID: | 21116297 |
出現コレクション: | 学術雑誌掲載論文等 |
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