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https://hdl.handle.net/2440/132913
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Type: | Journal article |
Title: | Microfluidic synthesis of curcumin loaded polymer nanoparticles with tunable drug loading and pH-triggered release |
Author: | Baby, T. Liu, Y. Yang, G. Chen, D. Zhao, C.X. |
Citation: | Journal of Colloid and Interface Science, 2021; 594:474-484 |
Publisher: | Elsevier |
Issue Date: | 2021 |
ISSN: | 0021-9797 1095-7103 |
Statement of Responsibility: | Thejus Baby, Yun Liu, Guangze Yang, Dong Chen, Chun-Xia Zhao |
Abstract: | Polymer nanoparticles (NPs) have attracted significant interest in the past years for drug delivery and triggered release. However, it remains a significant challenge to produce polymer NPs with controlled properties and tunable drug loading. Traditional nanoprecipitation often leads to low drug loading. This study reports the development of a new microfluidic nanoprecipitation approach for making polymer NPs with tunable drug loading up to 50%. The synthesized curcumin-loaded shellac NPs remain very stable for the period of our experiments (10 days) under acidic conditions (pH 4.5), but release the payload at neutral pH in a sustained manner. This work provides a new strategy for making drug-loaded polymer NPs with tunable drug loading and triggered release. |
Keywords: | Polymer nanoparticles; microfluidics; drug delivery; drug loading; pH triggered release |
Rights: | © 2021 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.jcis.2021.03.035 |
Grant ID: | http://purl.org/au-research/grants/arc/FT140100726 http://purl.org/au-research/grants/arc/DP200101238 |
Published version: | http://dx.doi.org/10.1016/j.jcis.2021.03.035 |
Appears in Collections: | Chemical Engineering publications |
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