Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/132913
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Type: Journal article
Title: Microfluidic synthesis of curcumin loaded polymer nanoparticles with tunable drug loading and pH-triggered release
Author: Baby, T.
Liu, Y.
Yang, G.
Chen, D.
Zhao, C.X.
Citation: Journal of Colloid and Interface Science, 2021; 594:474-484
Publisher: Elsevier
Issue Date: 2021
ISSN: 0021-9797
1095-7103
Statement of
Responsibility: 
Thejus Baby, Yun Liu, Guangze Yang, Dong Chen, Chun-Xia Zhao
Abstract: Polymer nanoparticles (NPs) have attracted significant interest in the past years for drug delivery and triggered release. However, it remains a significant challenge to produce polymer NPs with controlled properties and tunable drug loading. Traditional nanoprecipitation often leads to low drug loading. This study reports the development of a new microfluidic nanoprecipitation approach for making polymer NPs with tunable drug loading up to 50%. The synthesized curcumin-loaded shellac NPs remain very stable for the period of our experiments (10 days) under acidic conditions (pH 4.5), but release the payload at neutral pH in a sustained manner. This work provides a new strategy for making drug-loaded polymer NPs with tunable drug loading and triggered release.
Keywords: Polymer nanoparticles; microfluidics; drug delivery; drug loading; pH triggered release
Rights: © 2021 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.jcis.2021.03.035
Grant ID: http://purl.org/au-research/grants/arc/FT140100726
http://purl.org/au-research/grants/arc/DP200101238
Published version: http://dx.doi.org/10.1016/j.jcis.2021.03.035
Appears in Collections:Chemical Engineering publications

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