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https://hdl.handle.net/2440/133182
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Type: | Journal article |
Title: | Multi-day rTMS exerts site-specific effects on functional connectivity but does not influence associative memory performance |
Author: | Hendrikse, J. Coxon, J.P. Thompson, S. Suo, C. Fornito, A. Yücel, M. Rogasch, N.C. |
Citation: | Cortex, 2020; 132:423-440 |
Publisher: | Elsevier |
Issue Date: | 2020 |
ISSN: | 0010-9452 1973-8102 |
Statement of Responsibility: | Joshua Hendrikse, James P. Coxon, Sarah Thompson, Chao Suo, Alex Fornito, Murat Yücel and Nigel C. Rogasch |
Abstract: | Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique with the capacity to modulate brain network connectivity and cognitive function. Recent studies have demonstrated long-lasting improvements in associative memory and resting-state connectivity following multi-day repetitive TMS (rTMS) to individualised parietal-hippocampal networks. We aimed to assess the reproducibility and network- and cognitive-specificity of these effects following multi-day rTMS. Participants received four days of 20 Hz rTMS to a subject-specific region of left lateral parietal cortex exhibiting peak functional connectivity to the left hippocampus. In a separate week, the same stimulation protocol was applied to a subject-specific region of pre-supplementary motor area (pre-SMA) exhibiting peak functional connectivity to the left putamen. We assessed changes to associative memory before and after each week of stimulation (N = 39), and changes to resting-state functional connectivity before and after stimulation in week one (N = 36). We found no evidence of long-lasting enhancement of associative memory or increased parieto-hippocampal connectivity following multi-day rTMS to the parietal cortex, nor increased pre-SMA-putamen connectivity following multi-day rTMS to pre-SMA. Instead, we observed some evidence of site-specific modulations of functional connectivity lasting ~24 h, with reduced connectivity within targeted networks and increased connectivity across distinct non-targeted networks. Our findings suggest a complex interplay between multi-day rTMS and network connectivity. Further work is required to develop reliable rTMS paradigms for driving changes in functional connectivity between cortical and subcortical regions. |
Keywords: | rTMS; hippocampus; functional connectivity; memory; neuroplasticity |
Rights: | © 2020 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.cortex.2020.08.028 |
Grant ID: | NHMRC ARC |
Published version: | http://dx.doi.org/10.1016/j.cortex.2020.08.028 |
Appears in Collections: | Medicine publications |
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