Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/134987
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Type: | Journal article |
Title: | Transcriptional and post-transcriptional control of epithelial-mesenchymal plasticity: why so many regulators? |
Author: | Migault, M. Sapkota, S. Bracken, C.P. |
Citation: | Cellular and Molecular Life Sciences, 2022; 79(3):182-182 |
Publisher: | Springer Science and Business Media LLC |
Issue Date: | 2022 |
ISSN: | 1420-682X 1420-9071 |
Statement of Responsibility: | Melodie Migault, Sunil Sapkota, Cameron P. Bracken |
Abstract: | The dynamic transition between epithelial-like and mesenchymal-like cell states has been a focus for extensive investigation for decades, reflective of the importance of Epithelial-Mesenchymal Transition (EMT) through development, in the adult, and the contributing role EMT has to pathologies including metastasis and fibrosis. Not surprisingly, regulation of the complex genetic networks that underlie EMT have been attributed to multiple transcription factors and microRNAs. What is surprising, however, are the sheer number of different regulators (hundreds of transcription factors and microRNAs) for which critical roles have been described. This review seeks not to collate these studies, but to provide a perspective on the fundamental question of whether it is really feasible that so many regulators play important roles and if so, what does this tell us about EMT and more generally, the genetic machinery that controls complex biological processes. |
Keywords: | Epithelial-mesenchymal transition Transcription factor microRNA Cell signaling Gene networks Cancer |
Rights: | © The Author(s) 2022 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
DOI: | 10.1007/s00018-022-04199-0 |
Grant ID: | http://purl.org/au-research/grants/arc/FT190100544 http://purl.org/au-research/grants/arc/DP190103333 |
Published version: | http://dx.doi.org/10.1007/s00018-022-04199-0 |
Appears in Collections: | Medicine publications |
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hdl_134987.pdf | Published version | 1.47 MB | Adobe PDF | View/Open |
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