Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/135796
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Type: | Journal article |
Title: | A dual-target herbicidal inhibitor of lysine biosynthesis |
Author: | Mackie, E.R.R. Barrow, A.S. Christoff, R.M. Abbott, B.M. Gendall, A.R. Soares da Costa, T.P. |
Citation: | eLife, 2022; 11:1-11 |
Publisher: | eLife Sciences Publications Ltd |
Issue Date: | 2022 |
ISSN: | 2050-084X 2050-084X |
Statement of Responsibility: | Emily RR Mackie, Andrew S Barrow, Rebecca M Christoff, Belinda M Abbott, Anthony R Gendall, Tatiana P Soares da Costa |
Abstract: | Herbicides with novel modes of action are urgently needed to safeguard global agricultural industries against the damaging effects of herbicide-resistant weeds. We recently developed the first herbicidal inhibitors of lysine biosynthesis, which provided proof-of- concept for a promising novel herbicide target. In this study, we expanded upon our understanding of the mode of action of herbicidal lysine biosynthesis inhibitors. We previously postulated that these inhibitors may act as proherbicides. Here, we show this is not the case. We report an additional mode of action of these inhibitors, through their inhibition of a second lysine biosynthesis enzyme, and investigate the molecular determinants of inhibition. Furthermore, we extend our herbicidal activity analyses to include a weed species of global significance. |
Keywords: | Lysine Herbicides Plant Weeds Weed Control |
Rights: | Copyright Mackie et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
DOI: | 10.7554/eLife.78235 |
Grant ID: | http://purl.org/au-research/grants/arc/DE190100806 http://purl.org/au-research/grants/arc/IH180100006 |
Published version: | http://dx.doi.org/10.7554/elife.78235 |
Appears in Collections: | Agriculture, Food and Wine publications |
Files in This Item:
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hdl_135796.pdf | Published version | 5.81 MB | Adobe PDF | View/Open |
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