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https://hdl.handle.net/2440/137230
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Type: | Journal article |
Title: | The future burden of oesophageal and stomach cancers attributable to modifiable behaviours in Australia: a pooled cohort study. |
Author: | Laaksonen, M.A. Li, S. Canfell, K. MacInnis, R.J. Giles, G.G. Banks, E. Byles, J.E. Magliano, D.J. Shaw, J.E. Gill, T.K. Hirani, V. Cumming, R.G. Mitchell, P. Bonello, M. Australian cancer-PAF cohort consortium, Vajdic, C.M. |
Citation: | British Journal of Cancer, 2022; 128(6):1052-1069 |
Publisher: | Springer Nature |
Issue Date: | 2022 |
ISSN: | 0007-0920 1532-1827 |
Statement of Responsibility: | Maarit A. Laaksonen, Siqi Li, Karen Canfell, Robert J. MacInnis, Graham G. Giles, Emily Banks, Julie E. Byles, Dianna J. Magliano, Jonathan E. Shaw, Tiffany K. Gill, Vasant Hirani, Robert G. Cumming, Paul Mitchell, Michelle Bonello, the Australian cancer-PAF cohort consortium, Claire M. Vajdic |
Abstract: | Background We quantified the individual and joint contribution of contemporaneous causal behavioural exposures on the future burden of oesophageal and stomach cancers and their subtypes and assessed whether these burdens differ between population groups in Australia, as such estimates are currently lacking. Methods We combined hazard ratios from seven pooled Australian cohorts (N = 367,058) linked to national cancer and death registries with exposure prevalence from the 2017–2018 National Health Survey to estimate Population Attributable Fractions (PAFs) with 95% confidence intervals (CIs), accounting for competing risk of death. Results Current and past smoking explain 35.2% (95% CI = 11.7–52.4%), current alcohol consumption exceeding three drinks/day 15.7% (95% CI = 0.9–28.4%), and these exposures jointly 41.4% (95% CI = 19.8–57.3%) of oesophageal squamous cell carcinomas in Australia. Current and past smoking contribute 38.2% (95% CI = 9.4–57.9%), obesity 27.0% (95% CI = 0.6–46.4%), and these exposures jointly 54.4% (95% CI = 25.3–72.1%) of oesophageal adenocarcinomas. Overweight and obesity explain 36.1% (95% CI = 9.1–55.1%), current and past smoking 24.2% (95% CI = 4.2–40.0%), and these exposures jointly 51.2% (95% CI = 26.3–67.8%) of stomach cardia cancers. Several population groups had a significantly higher smoking-attributable oesophageal cancer burden, including men and those consuming excessive alcohol. Conclusions Smoking is the leading preventable behavioural cause of oesophageal cancers and overweight/obesity of stomach cancers. |
Keywords: | Australian cancer-PAF cohort consortium |
Rights: | © 2022, The Author(s), under exclusive licence to Springer Nature Limited |
DOI: | 10.1038/s41416-022-02104-x |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1082989 http://purl.org/au-research/grants/nhmrc/1079438 http://purl.org/au-research/grants/nhmrc/1118161 http://purl.org/au-research/grants/nhmrc/1136128 http://purl.org/au-research/grants/nhmrc/1053642 http://purl.org/au-research/grants/nhmrc/1060991 |
Published version: | http://dx.doi.org/10.1038/s41416-022-02104-x |
Appears in Collections: | Medicine publications |
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