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https://hdl.handle.net/2440/137694
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Type: | Journal article |
Title: | Effect of Docosahexaenoic Acid (DHA) Supplementation of Preterm Infants on Growth, Body Composition, and Blood Pressure at 7-Years Corrected Age: Follow-Up of a Randomized Controlled Trial |
Author: | Best, K.P. Sullivan, T.R. Gunaratne, A.W. Gould, J.F. Gibson, R.A. Collins, C.T. Makrides, M. Green, T.J. |
Citation: | Nutrients, 2023; 15(2):335-335 |
Publisher: | MDPI AG |
Issue Date: | 2023 |
ISSN: | 2072-6643 2072-6643 |
Statement of Responsibility: | Karen P. Best, Thomas R. Sullivan, Anoja W. Gunaratne, Jacqueline F. Gould, Robert A. Gibson, Carmel T. Collins, Maria Makrides, and Tim J. Green |
Abstract: | Aim: To determine if supplementation of infants born <33 weeks’ gestation with higher dose docosahexaenoic acid (DHA) affects growth, body composition, and blood pressure at 7 y corrected age (CA) and if treatment effects differed by infant sex at birth and birth weight strata (<1250 and ≥1250 g). Methods: Seven-year follow-up of an Australian multicenter randomized controlled trial in which 657 infants were fed high-DHA (≈1% total fatty acids) enteral feeds or standard-DHA (≈0.3% total fatty acids) from age 2–4 d until term CA. Seven-year CA outcomes were growth (weight, height), body composition (lean body mass, fat mass, waist, and hip circumference), and blood pressure. Results: There was no effect of high-DHA enteral feeds compared with standard-DHA on growth, body composition, and blood pressure at 7-year CA either overall or in subgroup analysis by sex. There was a significant interaction between high-DHA and birthweight strata on height at 7-y CA (p = 0.03). However, the post-hoc analyses by birthweight strata did not reach significance (p > 0.1). High-DHA group infants were more likely to be classified as obese (relative risk 1.6 (95% CI 1.0, 2.6); p = 0.05). Conclusions: DHA supplementation of premature infants did not affect growth, body composition, or blood pressure at 7-year CA overall by sex and birthweight strata. The finding of a higher risk of obesity in children who receive high-DHA needs to be interpreted with caution due to the small number of children classified as obese. |
Keywords: | docosahexaenoic acid; preterm infant; growth; body composition; blood pressure; !-3 long-chain polyunsaturated fatty acids |
Rights: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
DOI: | 10.3390/nu15020335 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/250322 http://purl.org/au-research/grants/nhmrc/508003 |
Published version: | http://dx.doi.org/10.3390/nu15020335 |
Appears in Collections: | Medicine publications |
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