Adelaide Research & Scholarship
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https://hdl.handle.net/2440/18987
| Type: | Thesis |
| Title: | The cerebral pharmacokinetics and pharmacodynamics of propofol in sheep / Guy Lawrence Ludbrook. |
| Author: | Ludbrook, Guy L. |
| Issue Date: | 1997 |
| School/Discipline: | Dept. of Anaesthesia and Intensive Care |
| Abstract: | This thesis examines the systemic and cerebral pharmacokinetics and pharmacodynamics of propofol following rapid administration, using regional pharmacokinetic techniques in a sheep preparation. New methods for measurement of cerebral blood flow, cerebral metabolic rate and depth of anaesthesia are developed and validated. The final studies show that distribution of propofol to the brain is dependent on cardiac output. |
| Dissertation Note: | Thesis (Ph.D.)--University of Adelaide, Dept. of Anaesthesia and Intensive Care, 1997? |
| Subject: | Anesthetics Pharmacokinetics. Anesthetics Physiological effect. Sheep as laboratory animals. Brain Effect of drugs on. |
| Description: | Bibliography: p. 207-236. 236 p. : ill. ; 30 cm. |
| Provenance: | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals |
| Appears in Collections: | Research Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01front.pdf | 1.03 MB | Adobe PDF | View/Open | |
| 02whole.pdf | 15.05 MB | Adobe PDF | View/Open |
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