Synthesis and structural characterization of carbosilane ruthenium(II) metallodendrons containing cymene units

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Authors
Maroto Díaz, MartaUniversity of Alcalá Author; Sanz del Olmo, NataliaUniversity of Alcalá Author; García Gallego, SandraUniversity of Alcalá Author; Gómez Ramírez, RafaelUniversity of Alcalá Author; Ortega Lopez, PaulaUniversity of Alcalá Author; [et al.]
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/46729
DOI: 10.1016/j.jorganchem.2019.120942
ISSN: 0022-328X
Date
2019-11-15
Embargo end date
2021-11-15
Academic Departments
Universidad de Alcalá. Departamento de Química Orgánica y Química Inorgánica
Teaching unit
Unidad docente Química Inorgánica
Funders
Ministerio de Economía y Competitividad
Comunidad de Madrid
Junta de Comunidades de Castilla-La Mancha
Unión Europea
Bibliographic citation
Journal of Organometallic Chemistry, 2019, v. 901, n. 120942
Keywords
Dendrons
Carbosilane
Schiff base
Ruthenium
Cymene
Allyl
Dimethylamino
Project
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-86224-P/ES/Dendronización como herramienta sintética de obtención de nanosistemas dendríticos específicamente diseñados para uso en aplicaciones biomédicas
info:eu-repo/grantAgreement/CAM/Programas de Actividades de I+D entre Grupos de Investigación de la Comunidad de Madrid en Biomedicina/B2017%2FBMD-3733/ES/Inmunidad tumoral e inmunoterapia del cáncer/IMMUNOTHERCAN-CM
info:eu-repo/grantAgreement/CAM//B2017%2FBMD-3703/ES/Nanosistemas dendríticos como agentes y vectores terapéuticos en distintas aplicaciones biomédicas (II)/NANODENDMED II-CM
info:eu-repo/grantAgreement/JCCM//SBPLY%2F17%2F180501%2F000358/ES/Nanosistemas dendríticos polifenólicos: aplicaciones en cosmética y biomedicina/DENPOLIFEN
info:eu-repo/grantAgreement/COST Association//COST Action CA17140/EU/Cancer nanomedicine - from the bench to the bedside (NANO2CLINIC)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
© Elsevier, 2019
Access rights
info:eu-repo/semantics/openAccess
Abstract
The development of heterofunctional carbosilane dendrons with Schiff base ligands in the focal point and allyl or dimethylamino groups in their periphery was achieved. The presence of donor atoms with coordinative capacity enabled the synthesis of ruthenium(II) metallodendrons with cymene units. Depending on the Schiff base ligand present at the focal point of the dendrons, the functionalization of these systems with dimethylamino groups improved the solubility with respect to their analogues withallyl groups, obtaining systems soluble in aqueous medium. The presence of chelate ligands enhanced the stability of the final compounds.This discovery is a starting point to accomplish stable metallodendrons that in future could be tested as possible anticancer agents.

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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
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