Development of biocomposite polymeric systems loaded with antibacterial nanoparticles for the coating of polypropylene biomaterials
Authors
Fernández Gutiérrez, Mar; Pérez Köhler, BárbaraIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/59253DOI: 10.3390/polym12081829
ISSN: 2073-4360
Date
2020Academic Departments
Universidad de Alcalá. Departamento de Cirugía, Ciencias Médicas y Sociales
Universidad de Alcalá. Departamento de Medicina y Especialidades Médicas
Teaching unit
Unidad Docente Especialidades médicas
Funders
Agencia Estatal de Investigación
Bibliographic citation
Polymers, 2020, v. 12, n. 1829, p. 1-15
Keywords
Biocomposite
Chitosan
Chlorhexidine
Coating
Hernia
Mesh infection
Nanoparticles
PLGA
Polypropylene
Rifampicin
Description / Notes
"Publicación presentada para sexenios"
Project
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89481-P/ES/FUNCIONALIZACION DE PROTESIS RETICULARES DE POLIPROPILENO CON RECUBRIMIENTOS ANTISEPTICOS, DESTINADOS A LA PREVENCION DE LA INFECCION EN REPARACION HERNIARIA/
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-84277-R/ES/MATERIALES BIOINSPIRADOS PARA INGENIERIA TISULAR Y LIBERACION CONTROLADA DE COMPONENTES BIOACTIVOS/
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
© 2020 by the authors
Attribution 4.0 International (CC BY 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
The development of a biocomposite polymeric system for the antibacterial coating of polypropylene mesh materials for hernia repair is reported. Coatings were constituted by a film of chitosan containing randomly dispersed poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles loaded with chlorhexidine or rifampicin. The chlorhexidine-loaded system exhibited a burst release during the first day reaching the release of the loaded drug in three or four days, whereas rifampicin was gradually released for at least 11 days. Both antibacterial coated meshes were highly active against Staphylococcus aureus and Staphylococcus epidermidis (106 CFU/mL), displaying zones of inhibition that lasted for 7 days (chlorhexidine) or 14 days (rifampicin). Apparently, both systems inhibited bacterial growth in the surrounding environment, as well as avoided bacterial adhesion to the mesh surface. These polymeric coatings loaded with biodegradable nanoparticles containing antimicrobials e_ectively precluded bacterial colonization of the biomaterial. Both biocomposites showed adequate performance and thus could have potential application in the design of antimicrobial coatings for the prophylactic coating of polypropylene materials for hernia repair.
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Files | Size | Format |
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development_fernandez_POLYMERS ... | 5.764Mb |
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