Rational Design and Synthesis of Efficient Sunscreens to Boost the Solar Protection Factor
Authors
García Iriepa, Cristina; Losantos, Raúl; Funes Ardoiz, Ignacio; Aguilera, José; Herrera Ceballos, Enrique; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/59900DOI: 10.1002/anie.201611627
ISSN: 1521-3773
Date
2017-03-01Affiliation
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaBibliographic citation
Angewandte Chemie International Edition, 2017, v. 56, n. 10, p. 2632-2635
Keywords
ab initio calculation
schromophores
photoprotection
sunscreens
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/aceptedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
© Wiley
Access rights
info:eu-repo/semantics/openAccess
Abstract
Skin cancer incidence has been increasing in the last decades, but most of the commercial formulations used as sunscreens are designed to protect only against solar erythema. Many of the active components present in sunscreens show critical weaknesses, such as low stability and toxicity. Thus, the development of more efficient components is an urgent health necessity and an attractive industrial target. We have rationally designed core moieties with increased photoprotective capacities and a new energy dissipation mechanism. Using these scaffolds, we have synthesized a series of compounds with tunable properties suitable for their use in sunscreens, and enhanced properties in terms of stability, light energy dissipation, and toxicity. Moreover, some representative compounds were included in final sunscreen formulations and a relevant solar protection factor boost was measured.
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Rational_Losantos_AngChem_2017.pdf | 831.6Kb |
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