Role of dipeptidyl peptidase-4 (DPP4) on COVID-19 physiopathology
Authors
Sebastián Martín, Alba; Sánchez Gómez, Belén; Mora Rodríguez, José María; Bort Bueno, Alicia Carmen; Díaz-Laviada Marturet, Inés CeciliaIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/60461DOI: 10.3390/biomedicines10082026
ISSN: 2227-9059
Date
2022-08-19Funders
Comunidad Autónoma de Madrid
Instituto de Salud Carlos III
Fundación Tatiana Pérez de Guzmán el Bueno
Ministerio de Educación, Cultura y Deporte
Bibliographic citation
Biomedicines, 2022, v. 10, n. 8 (2026), p. 1-21
Keywords
DPP4
CD26
type 2 diabetes
inflammation
SARS-CoV-2
COVID-19
gliptins
Project
info:eu-repo/grantAgreement/CAM//REACTUE-CM2021-02/ES//
info:eu-repo/grantAgreement/ISCIII//PI20%2F01327/ES//
info:eu-repo/grantAgreement/FT//2019-001/ES//
info:eu-repo/grantAgreement/UAH//CCG20%2FCC-011/ES//
info:eu-repo/grantAgreement/MECD/Programa Estatal de Promoción del Talento y su Empleabilidad en I+D+i/FPU17%2F03380/ES//
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
© 2022 by the authors
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
DPP4/CD26 is a single-pass transmembrane protein with multiple functions on glycemic control, cell migration and proliferation, and the immune system, among others. It has recently acquired an especial relevance due to the possibility to act as a receptor or co-receptor for SARS-CoV-2, as it has been already demonstrated for other coronaviruses. In this review, we analyze the evidence for the role of DPP4 on COVID-19 risk and clinical outcome, and its contribution to COVID-19 physiopathology. Due to the pathogenetic links between COVID-19 and diabetes mellitus and the hyperinflammatory response, with the hallmark cytokine storm developed very often during the disease, we dive deep into the functions of DPP4 on carbohydrate metabolism and immune system regulation. We show that the broad spectrum of functions regulated by DPP4 is performed both as a protease enzyme, as well as an interacting partner of other molecules on the cell surface. In addition, we provide an update of the DPP4 inhibitors approved by the EMA and/or the FDA, together with the newfangled approval of generic drugs (in 2021 and 2022). This review will also cover the effects of DPP4 inhibitors (i.e., gliptins) on the progression of SARS-CoV-2 infection, showing the role of DPP4 in this disturbing disease.
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Role_Sebastian_Biomedicine_2022.pdf | 1.103Mb |
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