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  5. Current understanding of biological identity at the nanoscale and future prospects
 
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Current understanding of biological identity at the nanoscale and future prospects

Author(s)
Dawson, Kenneth A.  
Yan, Yan  
Uri
http://hdl.handle.net/10197/12173
Date Issued
2021-03
Date Available
2021-05-18T15:36:46Z
Abstract
Nanoscale objects are processed by living organisms using highly evolved and sophisticated endogenous cellular networks, specifically designed to manage objects of this size. While these processes potentially allow nanostructures unique access to and control over key biological machineries, they are also highly protected by cell or host defence mechanisms at all levels. A thorough understanding of bionanoscale recognition events, including the molecules involved in the cell recognition machinery, the nature of information transferred during recognition processes and the coupled downstream cellular processing, would allow us to achieve a qualitatively novel form of biological control and advanced therapeutics. Here we discuss evolving fundamental microscopic and mechanistic understanding of biological nanoscale recognition. We consider the interface between a nanostructure and a target cell membrane, outlining the categories of nanostructure properties that are recognized, and the associated nanoscale signal transduction and cellular programming mechanisms that constitute biological recognition.
Sponsorship
Science Foundation Ireland
Other Sponsorship
Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment
Type of Material
Journal Article
Publisher
Springer Nature
Journal
Nature Nanotechnology
Volume
16
Issue
3
Start Page
229
End Page
242
Copyright (Published Version)
2021 Springer Nature
Subjects

Nanobiotechnology

Nanoparticles

Bionanoscale recognit...

DOI
10.1038/s41565-021-00860-0
Language
English
Status of Item
Peer reviewed
ISSN
1748-3387
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-nd/3.0/ie/
File(s)
No Thumbnail Available
Name

NNANO-20071994B Dawson_Accepted version.docx

Size

88.25 KB

Format

Unknown

Checksum (MD5)

3dc72f1531ca674020a0a8e183a9e6ce

Owning collection
Chemistry Research Collection
Mapped collections
Biomolecular and Biomedical Science Research Collection•
Centre for Bionano Interactions (CBNI) Research Collection•
Conway Institute Research Collection

Item descriptive metadata is released under a CC-0 (public domain) license: https://creativecommons.org/public-domain/cc0/.
All other content is subject to copyright.

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