Options
From amines to diketopiperazines: a one-pot approach
Author(s)
Date Issued
2010-03-31
Date Available
2012-06-13T15:33:27Z
Abstract
An efficient one-pot synthesis is described for the preparation of 1,4-disubstituted piperazine-2,5-diones
starting from a suitable amine and chloroacetyl chloride in the presence of an aqueous base. The resulting
chloroacetamide is cyclised in situ by employing the phase-transfer (PT) catalyst, benzyltriethylammonium
chloride (TEBA). The products are isolated in excellent yields of up to 90%.
starting from a suitable amine and chloroacetyl chloride in the presence of an aqueous base. The resulting
chloroacetamide is cyclised in situ by employing the phase-transfer (PT) catalyst, benzyltriethylammonium
chloride (TEBA). The products are isolated in excellent yields of up to 90%.
Sponsorship
Higher Education Authority
Irish Research Council for Science, Engineering and Technology
Type of Material
Journal Article
Publisher
Elsevier
Journal
Tetrahedron Letters
Volume
51
Issue
13
Start Page
1696
End Page
1697
Copyright (Published Version)
2010 Elsevier
Subject – LCSH
Organic cyclic compounds--Synthesis
Phase-transfer catalysts
Chlorides
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
File(s)
No Thumbnail Available
Name
O'Reilly Tet Lett 2010.doc
Size
96 KB
Format
Microsoft Word
Checksum (MD5)
6dba84471fe6b76688fbd3c870c81740
Owning collection