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  5. Biotransformation of fluorobiphenyl by Cunninghamella elegans
 
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Biotransformation of fluorobiphenyl by Cunninghamella elegans

Author(s)
Amadio, Jessica  
Murphy, Cormac D.  
Uri
http://hdl.handle.net/10197/3782
Date Issued
2010
Date Available
2012-09-04T15:59:46Z
Abstract
The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the culture supernatants with a variety of analytical techniques. 4-Fluorobiphenyl was principally transformed to 4-fluoro-4′-hydroxybiphenyl, but other mono- and dihydroxylated compounds were detected in organic extracts by gas chromatography–mass spectrometry. Additionally, fluorinated water-soluble products were detected by 19F NMR and were identified as sulphate and β-glucuronide conjugates. Other fluorobiphenyls (2-fluoro-, 4,4′-difluoro- and 2,3,4,5,6-pentafluoro-biphenyl) were catabolised by C. elegans, yielding mono- and dihydroxylated products, but phase II metabolites were detected from 4,4′-difluorobiphenyl only.
Sponsorship
Other funder
Other Sponsorship
EPA
Type of Material
Journal Article
Publisher
Springer
Journal
Applied Microbiology and Biotechnology
Volume
86
Issue
1
Start Page
345
End Page
351
Copyright (Published Version)
2009 Springer-Verlag
Subjects

Fluorine

Biphenyl

Metabolism

F-19 NMR

Subject – LCSH
Fluorine
Biphenyl compounds
Biotransformation (Metabolism)
Mucorales
DOI
10.1007/s00253-009-2346-4
Language
English
Status of Item
Peer reviewed
This item is made available under a Creative Commons License
https://creativecommons.org/licenses/by-nc-sa/1.0/
File(s)
No Thumbnail Available
Name

FBph manuscript revision.doc

Size

946 KB

Format

Microsoft Word

Checksum (MD5)

2072988917920dc68342bea7276253d6

Owning collection
Biomolecular and Biomedical Science Research Collection
Mapped collections
CSCB Research Collection

Item descriptive metadata is released under a CC-0 (public domain) license: https://creativecommons.org/public-domain/cc0/.
All other content is subject to copyright.

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