Advisor(s)
Abstract(s)
Two flavone glycosides, apigenin-6-C-glucoside (1) and lutelin-6-C-glucoside (2), and an anomeric mixture of
2,3-dygalloyl-4,6-HHDP-D-glucose (3a/3b) were isolated for the first time from Geranium molle L., a medicinal
plant used in the folk medicine of northeast of Portugal for the treatment of a variety of ailments, including
cancer. The cytotoxic activity of the isolated compounds was assessed against several human tumour cell lines
and non-tumour porcine liver primary cells. The anomeric mixture of ellagitannins 3a/3b, with the two anomers
showing considerably different hydrophobicities, was found to be significantly cytotoxic against cancer cells,
with only moderate hepatotoxicity.
Description
Keywords
Cytotoxic activity Geranium molle L. Phenolic compounds Secondary metabolites
Citation
Graça, V. C.; Calhelha, Ricardo C.; Nunes, Fernando M.; Berthet, Jérôme; Ferreira, Isabel C.F.R.; Santos, P. F. (2019). Isolation of secondary metabolites from Geranium molle L. with anticancer potential. Industrial Crops and Products. ISSN 0926-6690. 142, p. 1-5
