Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10198/12465
Título: | Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives |
Autor: | Petrova, Krasimira T. Potewar, Taterao M. Correia-da-Silva, Paula Barros, M. Teresa Calhelha, Ricardo C. Ćirić, Ana Soković, Marina Ferreira, Isabel C.F.R. |
Palavras-chave: | 1,2,3-Triazoles Antibacterial activity Antifungal activity Cytotoxic activity Sucrose |
Data: | 2015 |
Editora: | Elsevier |
Citação: | Petrova, Krasimira T.; Potewar, Taterao M.; Correia-da-Silva, Paula; Barros, M. Teresa; Calhelha, Ricardo C.; Ćirić, Ana; Soković, Marina; Ferreira, Isabel C.F.R. (2015). Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives. Carbohydrate Research. ISSN 1873-426X. 417, p. 66-71 |
Resumo: | A library of 1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-1,2,3-triazoles have been investigated for their antibacterial, antifungal and cytotoxic activities. Most of the target compounds showed good inhibitory activity against a variety of clinically and food contaminant important microbial pathogens. In particular, 1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-4-(4-pentylphenyl)-1,2,3- triazole (5) was highly active against all the tested bacteria with minimal inhibitory concentrations (MICs) ranging between 1.1 and 4.4 μM and bactericidal concentrations (MBCs) from 2.2 and 8.4 μM. The compound 1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-4-(4-bromophenyl)-1,2,3-triazole (3) showed antifungal activity with MICs from 0.6 to 4.8 μM and minimal fungicidal concentrations (MFCs) ranging between 1.2 and 8.9 μM. Furthermore, some of the compounds possessed moderate cytotoxicity against human breast, lung, cervical and hepatocellular carcinoma cell lines, without showing toxicity for nontumor liver cells. The above mentioned derivatives represent promising leads for the development of new generation of sugar-triazole anti fungal agents. |
Peer review: | yes |
URI: | http://hdl.handle.net/10198/12465 |
DOI: | 10.1016/j.carres.2015.09.003 |
ISSN: | 1873-426X |
Aparece nas colecções: | CIMO - Artigos em Revistas Indexados à WoS/Scopus |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Artigo 291.pdf | 271,11 kB | Adobe PDF | Ver/Abrir |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.