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http://hdl.handle.net/10198/20086
Título: | Phenolic profile and bioactive properties of carissa macrocarpa (Eckl.) A.DC.: An in vitro comparative study between leaves, stems, and flowers |
Autor: | Souilem, Fedia Dias, Maria Inês Barros, Lillian Calhelha, Ricardo C. Alves, Maria José Harzallah-Skhiri, Fethia Ferreira, Isabel C.F.R. |
Palavras-chave: | Bioactivities Carissa macrocarpa Pearson's correlation Phenolic profile Plant aerial parts |
Data: | 2019 |
Citação: | Souilem, Fedia; Dias, Maria Inês; Barros, Lillian; Calhelha, Ricardo C.; Alves, Maria José; Harzallah-Skhiri, Fethia; Ferreira, Isabel C.F.R. (2019). Phenolic profile and bioactive properties of carissa macrocarpa (Eckl.) A.DC.: An in vitro comparative study between leaves, stems, and flowers. Molecules. ISSN 1420-3049. 24, p. 1-12 |
Resumo: | The present work aimed to characterize leaves, stems, and flowers of Carissa macrocarpa (Eckl.) A.DC., by performing an analysis of the phenolic compounds by HPLC-DAD/ESI-MS, correlating them with bioactive properties, such as antioxidant, anti-inflammatory, cytotoxic, and antimicrobial activities. Thirty polyphenols were identified in the hydroethanolic extract, including phenolic acids, flavan-3-ols, and flavonol glycosides derivatives (which presented the highest number of identified compounds). However, flavan-3-ols showed the highest concentration in stems (mainly owing to the presence of dimers, trimmers, and tetramers of type B (epi)catechin). Leaves were distinguished by their high antioxidant and anti-inflammatory activities, as well as their bactericidal e ect against E. coli, while stems presented a higher cytotoxic activity and bactericidal e ect against Gram-positive bacteria. Moreover, a high correlation between the studied bioactivities and the presence of phenolic compounds was also verified. The obtained results bring added value to the studied plant species. |
Peer review: | yes |
URI: | http://hdl.handle.net/10198/20086 |
DOI: | 10.3390/molecules24091696 |
Aparece nas colecções: | CIMO - Artigos em Revistas Indexados à WoS/Scopus |
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