Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/115910
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial |
Autor: | Medina-Remón, Alexander; Tresserra-Rimbau, Anna; Pons, Antoni Aguiló; Tur, Josep Antoni; Martorell, M.; Ros, Emilio; Buil-Cosiales, Pilar; Sacanella, Emilio; Covas, María Isabel; Corella, Dolores; Salas-Salvadó, Jordi; Gómez-Gracia, Enrique; Ruiz-Gutiérrez, Valentina CSIC ; Ortega-Calvo, Manuel; García-Valdueza, M.; Arós, Fernando; Sáez, Guillermo; Serra-Majem, Lluís; Pintó, Xavier; Vinyoles, Ernest; Estruch, Ramón; Lamuela-Raventós, Rosa M. | Palabras clave: | Blood pressure Urinary polyphenol PREDIMED study Polyphenols Nitric oxide |
Fecha de publicación: | 2015 | Editor: | Elsevier | Citación: | Nutrition, Metabolism and Cardiovascular Diseases 25: 60- 67 (2015) | Resumen: | © 2014 Elsevier B.V. Background and aim: Hypertension is one of the main cardiovascular risk factors in the elderly. The aims of this work were to evaluate if a one-year intervention with two Mediterranean diets (Med-diet) could decrease blood pressure (BP) due to a high polyphenol consumption, and if the decrease in BP was mediated by plasma nitric oxide (NO) production. Methods and results: An intervention substudy of 200 participants at high cardiovascular risk was carried out within the PREDIMED trial. They were randomly assigned to a low-fat control diet or to two Med-diets, one supplemented with extra virgin olive oil (Med-EVOO) and the other with nuts (Med-nuts). Anthropometrics and clinical parameters were measured at baseline and after one year of intervention, as well as BP, plasma NO and total polyphenol excretion (TPE) in urine samples. Systolic and diastolic BP decreased significantly after a one-year dietary intervention with Med-EVOO and Med-nuts. These changes were associated with a significant increase in TPE and plasma NO. Additionally, a significant positive correlation was observed between changes in urinary TPE, a biomarker of TP intake, and in plasma NO (Beta=4.84; 95% CI: 0.57-9.10). Conclusions: TPE in spot urine sample was positively correlated with plasma NO in Med-diets supplemented with either EVOO or nuts. The statistically significant increases in plasma NO were associated with a reduction in systolic and diastolic BP levels, adding to the growing evidence that polyphenols might protect the cardiovascular system by improving the endothelial function and enhancing endothelial synthesis of NO. | URI: | http://hdl.handle.net/10261/115910 | DOI: | 10.1016/j.numecd.2014.09.001 | Identificadores: | doi: 10.1016/j.numecd.2014.09.001 issn: 1590-3729 |
Aparece en las colecciones: | (IG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
160
checked on 11-may-2024
WEB OF SCIENCETM
Citations
141
checked on 26-feb-2024
Page view(s)
400
checked on 11-may-2024
Download(s)
143
checked on 11-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.