Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/142703
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The establishment of the infant intestinal microbiome is not affected by rotavirus vaccination |
Autor: | Ang, Li; Arboleya, Silvia CSIC ORCID ; Lihua, Guo; Chuihui, Yuan; Nan, Qin; Suárez, Marta CSIC ORCID; Solís, Gonzalo; González de los Reyes-Gavilán, Clara CSIC ORCID ; Gueimonde Fernández, Miguel CSIC ORCID | Fecha de publicación: | 10-dic-2014 | Editor: | Nature Publishing Group | Citación: | Scientific Reports 4: 7417 (2014) | Resumen: | The microbial colonization of the intestine during the first months of life constitutes the most important process for the microbiota-induced host-homeostasis. Alterations in this process may entail a high-risk for disease in later life. However, the potential factors affecting this process in the infant are not well known. Moreover, the potential impact of orally administered vaccines upon the establishing microbiome remains unknown. Here we assessed the intestinal microbiome establishment process and evaluated the impact of rotavirus vaccination upon this process. Metagenomic, PCR-DGGE and faecal short chain fatty acids analyses were performed on faecal samples obtained from three infants before and after the administration of each dose of vaccine. We found a high inter-individual variability in the early life gut microbiota at microbial composition level, but a large similarity between the infants' microbiomes at functional level. Rotavirus vaccination did not show any major effects upon the infant gut microbiota. Thus, the individual microbiome establishment and development process seems to occur in a defined manner during the first stages of life and rotavirus vaccination appears to be inconsequential for this process. | Versión del editor: | https://doi.org/10.1038/srep07417 | URI: | http://hdl.handle.net/10261/142703 | DOI: | 10.1038/srep07417 | Identificadores: | issn: 2045-2322 |
Aparece en las colecciones: | (IPLA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
551827.pdf | 2,09 MB | Unknown | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
12
checked on 20-abr-2024
SCOPUSTM
Citations
16
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
14
checked on 23-feb-2024
Page view(s)
232
checked on 24-abr-2024
Download(s)
147
checked on 24-abr-2024