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Título: | Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents |
Autor: | Arouca, Aline; Meirhaeghe, Aline; Dallongeville, Jean; Moreno, Luis A.; Lourenço, Gustavo Jacob; Marcos, Ascensión CSIC ORCID; Huybrechts, Inge; Manios, Yannis; Lambrinou, Christina-Paulina; Gottrand, Frederic; Kafatos, Anthony; Kersting, Mathilde; Sjöström, Michael; Widhalm, Kurt; Ferrari, Marika; Molnár, Dénes; González-Gross, Marcela CSIC ORCID; Forsner, Maria; De Henauw, Stefaan; Michels, Nathalie | Palabras clave: | C-reactive protein Single nucleotide polymorphism Mediterranean diet Inflammation Interactions Nutrigenomics |
Fecha de publicación: | 2019 | Editor: | Elsevier | Citación: | Clinical Nutrition: (2019) | Resumen: | [Aim]: From a nutrigenetics perspective, we aim to investigate the moderating role of the Mediterranean diet and each of its subgroups in the association between C-reactive protein (CRP) gene polymorphisms and CRP blood concentration in adolescents. [Methods]: In 562 adolescents (13–17 y) of the European HELENA study, data was available on circulating CRP levels as inflammatory biomarker, three CRP gene SNPs (rs3093068, rs1204, rs1130864), food intake determined by a self-administered computerized 24 h-dietary recall for 2 days, and body composition. A 9-point Mediterranean diet score and each food subgroup were tested as moderator via SNP*diet interaction. Analyzes were adjusted for age, sex, puberty, adiposity and socioeconomic status. [Results]: The minor allele frequencies of rs3093068 and rs1130864 SNPs (GG and TT, respectively) were associated with higher CRP concentrations, while rs1205 (CT/TT) was associated with lower CRP concentrations. There were significant interactions between rs3093068 and Mediterranean diet (B = −0.1139, p = 0.011), or the fish food subgroup (B = −0.0090, p = 0.022), so that those with the highest genetic CRP risk underwent the highest CRP attenuation by a healthier diet. Although the effect of diet and SNP was substantial, the explained variance by interaction was only 1%. [Conclusion]: Greater adherence to the Mediterranean diet and particularly its fish component was associated with a lower CRP blood concentrations especially in those at highest genetic risk due to the rs3093068 SNP. | Descripción: | In Press. | Versión del editor: | https://doi.org/10.1016/j.clnu.2019.08.016 | URI: | http://hdl.handle.net/10261/203692 | DOI: | 10.1016/j.clnu.2019.08.016 | Identificadores: | doi: 10.1016/j.clnu.2019.08.016 e-issn: 1532-1983 issn: 0261-5614 |
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