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Título: | Supplementation with a carob (Ceratonia siliqua L.) fruit extract attenuates the cardiometabolic alterations associated with metabolic syndrome in mice |
Autor: | Fuente-Fernández, María de la; González-Hedström, Daniel; Amor, Sara; Tejera-Muñoz, Antonio; Fernández, Nuria; Monge, Luis; Almodóvar, Paula; Andrés-Delgado, Laura CSIC ORCID; Santamaría, Luis CSIC ORCID; Prodanov, M. CSIC ORCID ; Inarejos-García, Antonio M.; García-Villalón, Angel Luís; Granado, Miriam | Palabras clave: | Metabolic syndrome Coronary ischemia Carob Endothelial dysfunction Cardiovascular Insulin resistance |
Fecha de publicación: | 2020 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Antioxidants 9(4): 339 (2020) | Resumen: | The incidence of metabolic syndrome (MetS) is increasing worldwide which makes necessary the finding of new strategies to treat and/or prevent it. The aim of this study was to analyze the possible beneficial effects of a carob fruit extract (CSAT+®) on the cardiometabolic alterations associated with MetS in mice. 16-week-old C57BL/6J male mice were fed for 26 weeks either with a standard diet (chow) or with a diet rich in fats and sugars (HFHS), supplemented or not with 4.8% of CSAT+®. CSAT+® supplementation reduced blood glucose, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and circulating levels of total cholesterol, low-density lipoprotein (LDL) cholesterol (LDL-c), insulin, and interleukin-6 (IL-6). In adipose tissue and skeletal muscle, CSAT+® prevented MetS-induced insulin resistance, reduced macrophage infiltration and the expression of pro-inflammatory markers, and up-regulated the mRNA levels of antioxidant markers. Supplementation with CSAT+® prevented MetS-induced hypertension and decreased the vascular response of aortic rings to angiotensin II (AngII). Moreover, treatment with CSAT+® attenuated endothelial dysfunction and increased vascular sensitivity to insulin. In the heart, CSAT+® supplementation reduced cardiomyocyte apoptosis and prevented ischemia-reperfusion-induced decrease in cardiac contractility. The beneficial effects at the cardiovascular level were associated with a lower expression of pro-inflammatory and pro-oxidant markers in aortic and cardiac tissues. | Descripción: | This article belongs to the Special Issue Redox Regulation of Metabolic Syndrome: From Biochemical Mechanisms to Nutritional Interventions. | Versión del editor: | https://doi.org/10.3390/antiox9040339 | URI: | http://hdl.handle.net/10261/220217 | DOI: | 10.3390/antiox9040339 | E-ISSN: | 2076-3921 |
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